Table 1 Frequency and prognostic impact... | American Society of Hematology

Table 1

Frequency and prognostic impact of IDH2 gene mutations in CN-AML

Reference	n	Age range, y	IDH2^R172 mutation		IDH2^R140 mutation
Reference	n	Age range, y	Frequency	Prognosis	Frequency	Prognosis
Marcucci et al³	358	19-83	4%	↓ CR	16%	NC
Thol et al⁷	272	≤ 60	1.1%	No impact†	11%	No impact†
Paschka et al⁴	338	16-60	NC	NC	NC	NC
Boissel et al⁵	213	17-70	6%	↓ CR, ↑ RR, ↓ OS	—	—
Abbas et al⁸	353	15-77	14%†	No impact†	14%†	No impact†
Chou et al⁹	155‡	18-90	NC	↑ OS	NC	↑ OS

Reference	n	Age range, y	IDH2^R172 mutation		IDH2^R140 mutation
Reference	n	Age range, y	Frequency	Prognosis	Frequency	Prognosis
Marcucci et al³	358	19-83	4%	↓ CR	16%	NC
Thol et al⁷	272	≤ 60	1.1%	No impact†	11%	No impact†
Paschka et al⁴	338	16-60	NC	NC	NC	NC
Boissel et al⁵	213	17-70	6%	↓ CR, ↑ RR, ↓ OS	—	—
Abbas et al⁸	353	15-77	14%†	No impact†	14%†	No impact†
Chou et al⁹	155‡	18-90	NC	↑ OS	NC	↑ OS

ND indicates not done; NC, not communicated; CR, complete remission; OS, overall survival; —, not done; and RR, risk of relapse.

All IDH mutations.

All IDH2 mutations.

Patients with prognosis analysis.