Table 3 Ratio of observed (O) to... | American Society of Hematology

Table 3

Ratio of observed (O) to expected (E) cases of new solid cancers among recipients of allogeneic HCT using high-dose Bu-Cy conditioning for AML in CR1 and CML in CP1 by diagnosis and age at transplantation

Cancer site	Diagnosis				Age at transplantation
	AML (N = 1742)		CML (N = 2576)		< 35 y (N = 2264)		35-50 y (N = 1685)		> 50 y (N = 369)
	O	O/E	O	O/E	O	O/E	O	O/E	O	O/E
All sites	22	1.61*	44	1.31	13	1.73	33	1.23	20	1.57
Lip	0	0	4	36.58†	1	36.63	3	36.00†	0	0
Tongue	1	8.83	3	9.42*	1	19.20	2	7.36	1	9.26
Mouth	1	9.48	2	6.59	0	0	2	7.82	1	9.39
Hypopharynx	1	21.86	0	0	0	0	0	0	1	18.68
Esophagus	2	14.14*	4	9.32†	1	25.86	3	8.71*	2	10.66*
Colon	1	1.44	2	1.08	1	4.29	2	1.38	0	0
Bronchus and lung	7	6.32†	4	1.28	1	4.60	5	2.15	5	2.95
Melanoma, skin	2	2.17	2	1.01	2	2.78	2	1.22	0	0
Soft tissue	2	14.73*	1	3.54	3	20.88†	0	0	0	0
Breast	0	0	9	1.44	0	0	3	0.49	6	3.52*
Uterine cervix	1	2.48	2	2.25	1	2.21	2	2.68	0	0
Prostate	0	0	2	0.66	0	0	0	0	2	0.91
Testis	0	0	1	1.72	1	1.75	0	0	0	0
Kidney	0	0	1	1.03	0	0	1	1.25	0	0
Bladder	0	0	1	1.06	0	0	1	1.47	0	0
Brain and nervous system	1	2.87	3	4.19	0	0	2	3.72	2	10.70*
Adrenal gland	0	0	1	37.84	0	0	1	46.15	0	0
Other, unspecified‡	3	9.97†	2	2.42	1	6.48	4	6.13*	0	0

Cancer site	Diagnosis				Age at transplantation
	AML (N = 1742)		CML (N = 2576)		< 35 y (N = 2264)		35-50 y (N = 1685)		> 50 y (N = 369)
	O	O/E	O	O/E	O	O/E	O	O/E	O	O/E
All sites	22	1.61*	44	1.31	13	1.73	33	1.23	20	1.57
Lip	0	0	4	36.58†	1	36.63	3	36.00†	0	0
Tongue	1	8.83	3	9.42*	1	19.20	2	7.36	1	9.26
Mouth	1	9.48	2	6.59	0	0	2	7.82	1	9.39
Hypopharynx	1	21.86	0	0	0	0	0	0	1	18.68
Esophagus	2	14.14*	4	9.32†	1	25.86	3	8.71*	2	10.66*
Colon	1	1.44	2	1.08	1	4.29	2	1.38	0	0
Bronchus and lung	7	6.32†	4	1.28	1	4.60	5	2.15	5	2.95
Melanoma, skin	2	2.17	2	1.01	2	2.78	2	1.22	0	0
Soft tissue	2	14.73*	1	3.54	3	20.88†	0	0	0	0
Breast	0	0	9	1.44	0	0	3	0.49	6	3.52*
Uterine cervix	1	2.48	2	2.25	1	2.21	2	2.68	0	0
Prostate	0	0	2	0.66	0	0	0	0	2	0.91
Testis	0	0	1	1.72	1	1.75	0	0	0	0
Kidney	0	0	1	1.03	0	0	1	1.25	0	0
Bladder	0	0	1	1.06	0	0	1	1.47	0	0
Brain and nervous system	1	2.87	3	4.19	0	0	2	3.72	2	10.70*
Adrenal gland	0	0	1	37.84	0	0	1	46.15	0	0
Other, unspecified‡	3	9.97†	2	2.42	1	6.48	4	6.13*	0	0

P ≤ .05.

†

P ≤ .01.

‡

Includes metastatic adenocarcinoma, unknown primary site (N = 2), metastatic squamous cell carcinoma, unknown primary site (N = 2), and metastatic round cell tumor, unknown primary site (N = 1).

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