Risk factors for selected second solid cancers among allogeneic HCT recipients of high-dose Bu-Cy conditioning for AML in CR1 and CML in CP1
| Risk factor . | No. of second cancers . | Relative risk (95% CIs) . | P . |
|---|---|---|---|
| Cancer of trachea, bronchus, and lung | 11 | ||
| Age at transplantation | |||
| < 35 y | 1 | 1.0 | .01 |
| 35-50 y | 5 | 4.03 (0.5-36.4) | .22 |
| > 50 y | 5 | 17.9 (2.0-163.1) | .01 |
| Smoking prior to HCT | |||
| No | 1 | 1.0 | .02 |
| Yes | 9 | 11.6 (1.4-96.0) | .02 |
| Unknown | 1 | 3.8 (0.2-60.64) | .35 |
| Cancer of lip, tongue, and mouth | 11 | ||
| Chronic GVHD | |||
| No | 1 | 1.0 | .02 |
| Yes | 10 | 12.7 (1.6-99.1) |
| Risk factor . | No. of second cancers . | Relative risk (95% CIs) . | P . |
|---|---|---|---|
| Cancer of trachea, bronchus, and lung | 11 | ||
| Age at transplantation | |||
| < 35 y | 1 | 1.0 | .01 |
| 35-50 y | 5 | 4.03 (0.5-36.4) | .22 |
| > 50 y | 5 | 17.9 (2.0-163.1) | .01 |
| Smoking prior to HCT | |||
| No | 1 | 1.0 | .02 |
| Yes | 9 | 11.6 (1.4-96.0) | .02 |
| Unknown | 1 | 3.8 (0.2-60.64) | .35 |
| Cancer of lip, tongue, and mouth | 11 | ||
| Chronic GVHD | |||
| No | 1 | 1.0 | .02 |
| Yes | 10 | 12.7 (1.6-99.1) |