Characteristics of AML caused by C/EBPα mutants
| . | pMYs-IG/pMYs-IR (n = 8) . | Myc-Cm/pMYs-IR (n = 6) . | Myc-Cm/Flag-Nm (n = 8) . |
|---|---|---|---|
| WBC (/μL) | 9060 ± 1648 | 5816 ± 3128 | 36 675 ± 22 956 |
| Hb (g/dL) | 16.4 ± 3.2 | 12.4 ± 2.2 | 10.7 ± 2.3 |
| Plt (× 104/μL) | 79.4 ± 43.1 | 7.2 ± 4.5 | 19.8 ± 13.1 |
| BM count (× 107) | 3.34 ± 0.73 | 1.69 ± 0.30 | 2.83 ± 0.88 |
| Leukemic cells (%) | - | 60-92 | 72-94 |
| Liver weight (mg) | 1433 ± 153 | 2071 ± 1281 | 2441 ± 1315 |
| Spleen weight (mg) | 113 ± 24 | 476 ± 220 | 549 ± 239 |
| . | pMYs-IG/pMYs-IR (n = 8) . | Myc-Cm/pMYs-IR (n = 6) . | Myc-Cm/Flag-Nm (n = 8) . |
|---|---|---|---|
| WBC (/μL) | 9060 ± 1648 | 5816 ± 3128 | 36 675 ± 22 956 |
| Hb (g/dL) | 16.4 ± 3.2 | 12.4 ± 2.2 | 10.7 ± 2.3 |
| Plt (× 104/μL) | 79.4 ± 43.1 | 7.2 ± 4.5 | 19.8 ± 13.1 |
| BM count (× 107) | 3.34 ± 0.73 | 1.69 ± 0.30 | 2.83 ± 0.88 |
| Leukemic cells (%) | - | 60-92 | 72-94 |
| Liver weight (mg) | 1433 ± 153 | 2071 ± 1281 | 2441 ± 1315 |
| Spleen weight (mg) | 113 ± 24 | 476 ± 220 | 549 ± 239 |
Averages and standard deviations are shown. BM cells were isolated from both tibias and femurs.
WBC indicates white blood cell; Hb, hemoglobin; and Plt, platelets.