Outcomes of 12 patients after reduced-intensity unrelated cord blood transplantation
| Case no. . | Days to ANC > 0.5 × 109/L . | Days to PC > 20 × 109/L . | % Donor chimerism (days tested, methods) . | aGVHD . | cGVHD . | Discontinuation of IS (mo) . | Complications . | Survival (mo) . |
|---|---|---|---|---|---|---|---|---|
| 1 | 12 | 52 | 100 (14, FISH) | Grade II (skin) | No | Yes (3) | Possible IPA | Alive (91) |
| 2 | 20 | 64 | > 90 (49, PCR-STR) | Grade II (skin) | Limited | Yes (2) | No | Alive (90) |
| 3 | 26 | 42 | 100 (26, FISH) | No | No | Yes (26) | Yes | Alive (69) |
| 4 | 18 | 53 | 100 (18, FISH) | No | No | Yes (5) | Pneumocystis jirovecii, late GF, rescued by second RI-UCBT | Alive (69) |
| 5 | 16 | 26 | 96.6 (14, FISH) | Grade I (skin) | Limited | Yes (14) | Norwalk virus colitis, EBV-PTLD | Alive (39) |
| 6 | 28 | 64 | 99.6 (11, FISH) | No | NE | No | IPS | Dead; IPS (3) |
| 7 | No | No | 48.8 (10, FISH), 4.3 (15, FISH) | NE | NE | NE | Primary GF, rescued by second RI-UCBT | Alive (32) |
| 8 | 18 | 28 | 99.2 (13, FISH) | Grade II (skin, gut) | No | Yes (7) | CMV colitis, EBV-PTLD | Alive (28) |
| 9 | 28 | 43 | > 90 (14, PCR-STR) | Grade I (skin) | NE | No | HSV pneumonia, IPS | Dead; IPS (3) |
| 10 | 15 | 27 | 99 (73, FISH) | No | Limited | No | No | Alive (22) |
| 11 | 15 | 27 | 100 (20, FISH) | Grade II (skin, gut) | No | No | No | Alive (22) |
| 12 | 13 | 28 | 100 (14, FISH) | Grade II (gut) | No | No | No | Alive (14) |
| Case no. . | Days to ANC > 0.5 × 109/L . | Days to PC > 20 × 109/L . | % Donor chimerism (days tested, methods) . | aGVHD . | cGVHD . | Discontinuation of IS (mo) . | Complications . | Survival (mo) . |
|---|---|---|---|---|---|---|---|---|
| 1 | 12 | 52 | 100 (14, FISH) | Grade II (skin) | No | Yes (3) | Possible IPA | Alive (91) |
| 2 | 20 | 64 | > 90 (49, PCR-STR) | Grade II (skin) | Limited | Yes (2) | No | Alive (90) |
| 3 | 26 | 42 | 100 (26, FISH) | No | No | Yes (26) | Yes | Alive (69) |
| 4 | 18 | 53 | 100 (18, FISH) | No | No | Yes (5) | Pneumocystis jirovecii, late GF, rescued by second RI-UCBT | Alive (69) |
| 5 | 16 | 26 | 96.6 (14, FISH) | Grade I (skin) | Limited | Yes (14) | Norwalk virus colitis, EBV-PTLD | Alive (39) |
| 6 | 28 | 64 | 99.6 (11, FISH) | No | NE | No | IPS | Dead; IPS (3) |
| 7 | No | No | 48.8 (10, FISH), 4.3 (15, FISH) | NE | NE | NE | Primary GF, rescued by second RI-UCBT | Alive (32) |
| 8 | 18 | 28 | 99.2 (13, FISH) | Grade II (skin, gut) | No | Yes (7) | CMV colitis, EBV-PTLD | Alive (28) |
| 9 | 28 | 43 | > 90 (14, PCR-STR) | Grade I (skin) | NE | No | HSV pneumonia, IPS | Dead; IPS (3) |
| 10 | 15 | 27 | 99 (73, FISH) | No | Limited | No | No | Alive (22) |
| 11 | 15 | 27 | 100 (20, FISH) | Grade II (skin, gut) | No | No | No | Alive (22) |
| 12 | 13 | 28 | 100 (14, FISH) | Grade II (gut) | No | No | No | Alive (14) |
ANC indicates absolute neutrophil count; PC, platelet count; aGVHD, acute graft-versus-host disease; cGVHD, chronic graft-versus-host disease; IS, immunosuppressant; FISH, fluorescence in situ hybridization; PCR-STR, PCR of short tandem repeat; NE, not evaluable; IPA, invasive pulmonary aspergillosis; EBV-PTLD, Epstein-Barr virus–associated posttransplantation lymphoproliferative disorder; and IPS, idiopathic pneumonia syndrome.