Investigation for risk stratification
| Investigation recommended for risk stratification |
| Serum albumin and β2-microglobulin to determine ISS stage |
| Bone marrow examination for t(4;14), t(14;16), and del(17p) on identified PCs by FISH |
| LDH |
| Immunoglobulin type IgA |
| Histology: plasmablastic disease |
| Additional investigation for risk stratification |
| Cytogenetics |
| Gene expression profiling |
| Labeling index |
| MRI/PET scan |
| DNA copy number alteration by CGH/SNP array |
| Investigation recommended for risk stratification |
| Serum albumin and β2-microglobulin to determine ISS stage |
| Bone marrow examination for t(4;14), t(14;16), and del(17p) on identified PCs by FISH |
| LDH |
| Immunoglobulin type IgA |
| Histology: plasmablastic disease |
| Additional investigation for risk stratification |
| Cytogenetics |
| Gene expression profiling |
| Labeling index |
| MRI/PET scan |
| DNA copy number alteration by CGH/SNP array |
PCs indicates plasma cells; FISH, fluorescence in situ hybridization; LDH, lactate dehydrogenase; MRI/PET, magnetic resonance imaging/positron emission tomography; and CGH/SNP, comparative genomic hybridization/single nucleotide polymorphism.