Table 1

Demographic and clinical features of patients with and without C5a-mediated neutrophil dysfunction.

VariableDysfunctionNo DysfunctionP
No. of patients 38 22  
Median age, y (range) 58 (20-88) 62 (26-80) .9* 
Male, % 50% 64% .42 
Admitted to ICU with sepsis, % 32% 45% .42 
Surgical patients, % 32% 31% 1 
Receiving corticosteroids, % 26% 19% .75 
Comorbid conditions, median (IQR; Charlson index) 3 (2-5) 3 (1-4) .52* 
Intubated, % 92% 91% 1 
With a central venous catheter, % 82% 77% .74 
APACHE II score, median (IQR) 21 (19-29) 22 (15-29) .81* 
Acquiring infection in ICU, % 53% 9% .0007 
VariableDysfunctionNo DysfunctionP
No. of patients 38 22  
Median age, y (range) 58 (20-88) 62 (26-80) .9* 
Male, % 50% 64% .42 
Admitted to ICU with sepsis, % 32% 45% .42 
Surgical patients, % 32% 31% 1 
Receiving corticosteroids, % 26% 19% .75 
Comorbid conditions, median (IQR; Charlson index) 3 (2-5) 3 (1-4) .52* 
Intubated, % 92% 91% 1 
With a central venous catheter, % 82% 77% .74 
APACHE II score, median (IQR) 21 (19-29) 22 (15-29) .81* 
Acquiring infection in ICU, % 53% 9% .0007 

ICU indicates intensive care unit; IQR, interquartile range; and APACHE, Acute Physiology and Chronic Health Evaluation.

*

Mann-Whitney test.

Fisher exact test.

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