Laboratory tests for multiple myeloma
| History and physical examination |
| Complete blood count and differential; peripheral blood smear |
| Chemistry screen, including calcium and creatinine |
| Serum protein electrophoresis, immunofixation |
| Nephelometric quantification of serum immunoglobulins |
| Routine urinalysis, 24-hour urine collection for electrophoresis and immunofixation |
| Bone marrow aspirate and/or biopsy |
| Cytogenetics (metaphase karyotype and FISH) |
| Radiologic skeletal bone survey, including spine, pelvis, skull, humeri, and femurs; magnetic resonance imaging in certain circumstances |
| Serum β2-microglobulin and lactate dehydrogenase |
| Measurement of serum-free light chains |
| History and physical examination |
| Complete blood count and differential; peripheral blood smear |
| Chemistry screen, including calcium and creatinine |
| Serum protein electrophoresis, immunofixation |
| Nephelometric quantification of serum immunoglobulins |
| Routine urinalysis, 24-hour urine collection for electrophoresis and immunofixation |
| Bone marrow aspirate and/or biopsy |
| Cytogenetics (metaphase karyotype and FISH) |
| Radiologic skeletal bone survey, including spine, pelvis, skull, humeri, and femurs; magnetic resonance imaging in certain circumstances |
| Serum β2-microglobulin and lactate dehydrogenase |
| Measurement of serum-free light chains |