Patients with and without HHV-6 reactivation who had > 0.75 SD decline in neurocognitive assessment score from baseline to 12-week follow-up
| Domain (specific tests used for different ages) . | HHV-6, no. (%) (n = 101) . | No HHV-6, no. (%) (n = 189) . | P . |
|---|---|---|---|
| Cognitive flexibility and divided attention (Trail Making Test B, NEPSY Visual Attention) | 19 (40) | 23 (25) | .08 |
| Attention and processing speed (Digit Symbol Coding Test, WISC-IV coding B, WPPSI Coding) | 11 (22) | 3 (3) | < .001 |
| Concentration (Stroop color/words, NEPSY Speeded Naming) | 7 (15) | 4 (4) | .05 |
| Verbal fluency (COWAT, NEPSY Verbal Fluency) | 13 (27) | 14 (15) | .09 |
| Visual memory (Faces WMSIII and Faces CMS) | 6 (13) | 6 (7) | .23 |
| Verbal memory (WRAML 2) | 5 (10) | 6 (6) | .44 |
| Visuospatial perception (Judgment of Line Orientation, NEPSY Arrows) | 9 (18) | 14 (15) | .61 |
| Fine motor speed and coordination (Grooved Peg Board) | 9 (18) | 25 (27) | .23 |
| Domain (specific tests used for different ages) . | HHV-6, no. (%) (n = 101) . | No HHV-6, no. (%) (n = 189) . | P . |
|---|---|---|---|
| Cognitive flexibility and divided attention (Trail Making Test B, NEPSY Visual Attention) | 19 (40) | 23 (25) | .08 |
| Attention and processing speed (Digit Symbol Coding Test, WISC-IV coding B, WPPSI Coding) | 11 (22) | 3 (3) | < .001 |
| Concentration (Stroop color/words, NEPSY Speeded Naming) | 7 (15) | 4 (4) | .05 |
| Verbal fluency (COWAT, NEPSY Verbal Fluency) | 13 (27) | 14 (15) | .09 |
| Visual memory (Faces WMSIII and Faces CMS) | 6 (13) | 6 (7) | .23 |
| Verbal memory (WRAML 2) | 5 (10) | 6 (6) | .44 |
| Visuospatial perception (Judgment of Line Orientation, NEPSY Arrows) | 9 (18) | 14 (15) | .61 |
| Fine motor speed and coordination (Grooved Peg Board) | 9 (18) | 25 (27) | .23 |
WPPSI indicates Wechsler Preschool and Primary Scale of Intelligence; COWAT, Controlled Oral Word Association Test; WMSIII, Wechsler Memory Scale III; CMS, Children's Memory Scale; and WRAML, Wide Range Assessment of Memory and Learning.