IL-18 levels detected in the serum of rhesus macaques receiving 12 daily infusions of rhIL-15
| Macaque ID . | rhIL-15 dose, μg/kg . | IL-18 level, pg/mL . | ||||
|---|---|---|---|---|---|---|
| Pre-therapy . | Day 8 . | Day 13 . | Day 15 . | Day 22 . | ||
| 395 | Vehicle | 82 | 66 | ND | ND | ND |
| CFIT | Vehicle | 47 | 56 | ND | ND | ND |
| XDD | Vehicle | 79 | 61 | ND | ND | ND |
| XAF | Vehicle | 189 | 170 | ND | ND | ND |
| XCJ | Vehicle | 131 | 160 | ND | ND | ND |
| CK3C | Vehicle | 132 | 128 | ND | ND | ND |
| Mean | 110 | 107 | ||||
| SD | 51 | 52 | ||||
| XFH | 10 | 192 | 620 | 560 | ND | ND |
| DA5F | 10 | 192 | 389 | 485 | ND | ND |
| CF5F | 10 | 371 | 531 | 532 | ND | ND |
| 446 | 10 | 113 | 373 | 414 | ND | 169 |
| XDT | 10 | 179 | 544 | 547 | ND | 239 |
| CJSP | 10 | 173 | 417 | 507 | ND | 231 |
| Mean | 203 | 479 | 508 | 213 | ||
| SD | 87 | 100 | 53 | 38 | ||
| RQ3552 | 20 | 157 | 339 | 390 | ND | ND |
| H450 | 20 | 134 | 299 | 543 | ND | ND |
| CK3D | 20 | 115 | 448 | 490 | ND | ND |
| VTC | 20 | 132 | 376 | ND | 303 | 154 |
| VVX | 20 | 152 | 688 | 650 | ND | 208 |
| CK2X | 20 | 95 | 422 | 649 | ND | 230 |
| Mean | 131 | 429 | 544 | 197 | ||
| SD | 23 | 138 | 111 | 39 | ||
| CJ64 | 50 | 199 | 703 | 712 | ND | ND |
| OIE123 | 50 | 100 | 508 | 568 | ND | ND |
| CF65 | 50 | 86 | 408 | 615 | ND | ND |
| XFK | 50 | 103 | 320 | ND | 343 | 216 |
| CK18 | 50 | 62 | 388 | 757 | ND | 231 |
| CF4C | 50 | 150 | 596 | 632 | ND | 201 |
| Mean | 117 | 487 | 657 | 216 | ||
| SD | 50 | 143 | 76 | 15 | ||
| Macaque ID . | rhIL-15 dose, μg/kg . | IL-18 level, pg/mL . | ||||
|---|---|---|---|---|---|---|
| Pre-therapy . | Day 8 . | Day 13 . | Day 15 . | Day 22 . | ||
| 395 | Vehicle | 82 | 66 | ND | ND | ND |
| CFIT | Vehicle | 47 | 56 | ND | ND | ND |
| XDD | Vehicle | 79 | 61 | ND | ND | ND |
| XAF | Vehicle | 189 | 170 | ND | ND | ND |
| XCJ | Vehicle | 131 | 160 | ND | ND | ND |
| CK3C | Vehicle | 132 | 128 | ND | ND | ND |
| Mean | 110 | 107 | ||||
| SD | 51 | 52 | ||||
| XFH | 10 | 192 | 620 | 560 | ND | ND |
| DA5F | 10 | 192 | 389 | 485 | ND | ND |
| CF5F | 10 | 371 | 531 | 532 | ND | ND |
| 446 | 10 | 113 | 373 | 414 | ND | 169 |
| XDT | 10 | 179 | 544 | 547 | ND | 239 |
| CJSP | 10 | 173 | 417 | 507 | ND | 231 |
| Mean | 203 | 479 | 508 | 213 | ||
| SD | 87 | 100 | 53 | 38 | ||
| RQ3552 | 20 | 157 | 339 | 390 | ND | ND |
| H450 | 20 | 134 | 299 | 543 | ND | ND |
| CK3D | 20 | 115 | 448 | 490 | ND | ND |
| VTC | 20 | 132 | 376 | ND | 303 | 154 |
| VVX | 20 | 152 | 688 | 650 | ND | 208 |
| CK2X | 20 | 95 | 422 | 649 | ND | 230 |
| Mean | 131 | 429 | 544 | 197 | ||
| SD | 23 | 138 | 111 | 39 | ||
| CJ64 | 50 | 199 | 703 | 712 | ND | ND |
| OIE123 | 50 | 100 | 508 | 568 | ND | ND |
| CF65 | 50 | 86 | 408 | 615 | ND | ND |
| XFK | 50 | 103 | 320 | ND | 343 | 216 |
| CK18 | 50 | 62 | 388 | 757 | ND | 231 |
| CF4C | 50 | 150 | 596 | 632 | ND | 201 |
| Mean | 117 | 487 | 657 | 216 | ||
| SD | 50 | 143 | 76 | 15 | ||
ND indicates not determined.