Table 2

Nonredundant candidate gene SNPs associated with fibrinogen in EAs

ChromosomeGenedbSNP reference numberMinor allele frequencyMeta-analysis regression coefficient (SE)Meta-analysis PComment
1q21 IL6R rs7529229 (T > C) 0.41 −0.050 (0.009) 8.3 × 10−8 Confirmation of previous GWAS result 
1q44 NLRP3 rs4925659 (G > A) 0.38 0.052 (0.010) 5.3 × 10−8 Confirmation of previous GWAS result 
1q44 NLRP3 rs12239046 (C > T) 0.39 −0.049 (0.010) 3.3 × 10−7 Fine-mapping of previous GWAS result 
2q13 IL1RN rs315921 (G > A) 0.18 −0.057 (0.012) 2.6 × 10−6 Confirmation of previous GWAS result 
2q13 IL1RN rs4251961 (T > C) 0.38 0.040 (0.0102) 2.1 × 10−5 Fine-mapping of previous GWAS result 
2q34 CPS1 rs7422339 (C > A) 0.32 −0.060 (0.010) 1.9 × 10−9 Confirmation of previous GWAS result 
2q37 HDLBP rs6752050 (T > C) 0.15 −0.063 (0.013) 1.2 × 10−6 New association in current study 
3q22 PCCB rs3821445 (A > G) 0.20 0.056 (0.012) 1.2 × 10−6 Confirmation of previous GWAS result 
4q32 FGB rs1800787 (C > T) 0.21 0.151 (0.012) 1.4 × 10−9 Confirmation of previous GWAS result 
4q32 FGB rs6054 (C > T) 0.004 −0.580 (0.068) 1.2 × 10−17 New association in current study 
4q32 FGG rs2066861 (C > T) 0.23 −0.068 (0.011) 4.2 × 10−10* Fine-mapping of previous GWAS result 
5q31 SLC22A5-IRF1 rs6874639† (A > G) 0.19 −0.128 (0.014) 4.3 × 10−20 Confirmation of previous GWAS result 
5q31 IRF1 rs6873426† (G > T) 0.31 0.089 (0.014) 2.1 × 10−10 Fine-mapping of previous GWAS result 
20q13 HNF4A rs1800961 (C > T) 0.03 −0.124 (0.027) 4.5 × 10−6 New association in current study 
ChromosomeGenedbSNP reference numberMinor allele frequencyMeta-analysis regression coefficient (SE)Meta-analysis PComment
1q21 IL6R rs7529229 (T > C) 0.41 −0.050 (0.009) 8.3 × 10−8 Confirmation of previous GWAS result 
1q44 NLRP3 rs4925659 (G > A) 0.38 0.052 (0.010) 5.3 × 10−8 Confirmation of previous GWAS result 
1q44 NLRP3 rs12239046 (C > T) 0.39 −0.049 (0.010) 3.3 × 10−7 Fine-mapping of previous GWAS result 
2q13 IL1RN rs315921 (G > A) 0.18 −0.057 (0.012) 2.6 × 10−6 Confirmation of previous GWAS result 
2q13 IL1RN rs4251961 (T > C) 0.38 0.040 (0.0102) 2.1 × 10−5 Fine-mapping of previous GWAS result 
2q34 CPS1 rs7422339 (C > A) 0.32 −0.060 (0.010) 1.9 × 10−9 Confirmation of previous GWAS result 
2q37 HDLBP rs6752050 (T > C) 0.15 −0.063 (0.013) 1.2 × 10−6 New association in current study 
3q22 PCCB rs3821445 (A > G) 0.20 0.056 (0.012) 1.2 × 10−6 Confirmation of previous GWAS result 
4q32 FGB rs1800787 (C > T) 0.21 0.151 (0.012) 1.4 × 10−9 Confirmation of previous GWAS result 
4q32 FGB rs6054 (C > T) 0.004 −0.580 (0.068) 1.2 × 10−17 New association in current study 
4q32 FGG rs2066861 (C > T) 0.23 −0.068 (0.011) 4.2 × 10−10* Fine-mapping of previous GWAS result 
5q31 SLC22A5-IRF1 rs6874639† (A > G) 0.19 −0.128 (0.014) 4.3 × 10−20 Confirmation of previous GWAS result 
5q31 IRF1 rs6873426† (G > T) 0.31 0.089 (0.014) 2.1 × 10−10 Fine-mapping of previous GWAS result 
20q13 HNF4A rs1800961 (C > T) 0.03 −0.124 (0.027) 4.5 × 10−6 New association in current study 

dbSNP indicates National Center for Biotechnology Information (NCBI) Single Nucleotide Polymorphism Database; and SE, standard error of regression coefficient.

*

Indicates meta-analysis P value for heterogeneity < .01.

†

SNP genotype imputed from HapMap CEU (EA) genotype data.

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