Nonredundant candidate gene tagSNPs associated with fibrinogen in AAs
| Chromosome . | Gene . | dbSNP reference number . | Minor allele frequency . | Meta-analysis regression coefficient (SE) . | Meta-analysis P . | Comment . |
|---|---|---|---|---|---|---|
| 4q32 | FGG | rs2066874 (T > C) | 0.03 | −0.333 (0.050) | 2.9 × 10−11 | Replication of previous candidate gene study |
| 4q32 | FGA | rs2070017 (C > T) | 0.11 | −0.163 (0.028) | 4.8 × 10−9 | Replication of previous candidate gene study |
| 4q32 | FGA | rs10050257 (T > G) | 0.06 | −0.213 (0.037) | 7.7 × 10−9 | New association in current study |
| 4q32 | FGB | rs1800787 (C > T) | 0.10 | 0.146 (0.029) | 4.7 × 10−7 | Replication of previous candidate gene study |
| 4q32 | FGB | rs6058 (G > T) | 0.07 | −0.170 (0.036) | 9.5 × 10−7 | Replication of previous candidate gene study |
| 4q32 | FGA-FGG | rs10034922* (C > T) | 0.19 | −0.121 (0.024) | 3.9 × 10−7 | New association in current study |
| 4q32 | FGB | rs4463047* (C > T) | 0.13 | −0.179 (0.036) | 7.3 × 10−7 | New association in current study |
| Chromosome . | Gene . | dbSNP reference number . | Minor allele frequency . | Meta-analysis regression coefficient (SE) . | Meta-analysis P . | Comment . |
|---|---|---|---|---|---|---|
| 4q32 | FGG | rs2066874 (T > C) | 0.03 | −0.333 (0.050) | 2.9 × 10−11 | Replication of previous candidate gene study |
| 4q32 | FGA | rs2070017 (C > T) | 0.11 | −0.163 (0.028) | 4.8 × 10−9 | Replication of previous candidate gene study |
| 4q32 | FGA | rs10050257 (T > G) | 0.06 | −0.213 (0.037) | 7.7 × 10−9 | New association in current study |
| 4q32 | FGB | rs1800787 (C > T) | 0.10 | 0.146 (0.029) | 4.7 × 10−7 | Replication of previous candidate gene study |
| 4q32 | FGB | rs6058 (G > T) | 0.07 | −0.170 (0.036) | 9.5 × 10−7 | Replication of previous candidate gene study |
| 4q32 | FGA-FGG | rs10034922* (C > T) | 0.19 | −0.121 (0.024) | 3.9 × 10−7 | New association in current study |
| 4q32 | FGB | rs4463047* (C > T) | 0.13 | −0.179 (0.036) | 7.3 × 10−7 | New association in current study |
dbSNP indicates NCBI Single Nucleotide Polymorphism Database; and SE, standard error of regression coefficient.
SNP genotype imputed from HapMap EA (CEU) plus Yoruban (YRI) genotype data.