Table 4 Comparison of SNPs associated... | American Society of Hematology

Table 4

Comparison of SNPs associated with circulating levels of fibrinogen in EAs and AAs

Chromosome	Coordinate	Gene	SNP	Allele 1	Allele 2	Variant type	EAs			AAs
Chromosome	Coordinate	Gene	SNP	Allele 1	Allele 2	Variant type	CAF*	β	P	CAF*	β	P
1	152687402	IL6R	rs7529229	t	c	intron	0.41	−0.050	8.3 × 10⁻⁸	0.64	−0.012	.51
1	152685503	IL6R	rs8192284	a	c	coding-nonsynon	0.40	−0.046	9.3 × 10⁻⁷	0.14	−0.060	.02
1	245670086	NLRP3	rs4925659	g	a	intron	0.38	0.052	5.3 × 10⁻⁸	0.17	0.018	.44
1	245668218	NLRP3	rs12239046	c	t	intron	0.39	−0.049	3.3 × 10⁻⁷	0.49	−0.039	.02
2	113588522	IL1RN	rs315921	g	a	5′ upstream	0.18	−0.057	2.6 × 10⁻⁶	0.03	0.030	.54
2	113590938	IL1RN	rs4251961	t	c	5′ upstream	0.38	0.040	2.1 × 10⁻⁵	0.18	0.097	1.8 × 10⁻⁵
2	211248752	CPS1	rs7422339	c	a	coding-nonsynon	0.32	−0.060	1.9 × 10⁻⁹	0.37	−0.021	.25
2	241877453	HDLBP	rs6752050	t	c	untranslated	0.15	−0.063	1.2 × 10⁻⁶	0.03	−0.033	.51
3	137485499	PCCB	rs3821445	a	g	intron	0.20	0.056	1.2 × 10⁻⁶	0.11	−0.005	.85
4	155703465	FGB	rs1800787	c	t	5′ upstream	0.21	0.151	1.4 × 10⁻³⁹	0.10	0.146	4.7 × 10⁻⁷
4	155709058	FGB	rs6054	c	t	coding-nonsynon	0.004	−0.580	1.2 × 10⁻¹⁷	0.001	−0.343	.14
4	155746886	FGG	rs2066861	c	t	5′ upstream	0.23	−0.068	4.2 × 10⁻¹⁰	0.29	−0.073	6.8 × 10⁻⁵
4	155749031	FGG	rs2066874	t	c	intron	8 × 10⁻⁵	−0.289	.62	0.03	−0.333	2.9 × 10⁻¹¹
4	155734845	FGA	rs10050257	t	g	5′ upstream	0.0009	−0.288	.10	0.06	−0.213	7.7 × 10⁻⁹
4	155729726	FGA	rs2070017	c	t	intron	0.002	−0.303	.03	0.11	−0.163	4.8 × 10⁻⁹
4	155709794	FGB	rs6058	g	t	coding-synon	0.0001	−0.676	.02	0.07	−0.170	9.5 × 10⁻⁷
4	155740078	FGA-FGG	rs10034922†	c	t	intergenic	0.01	0.115	.09	0.19	−0.121	3.9 × 10⁻⁷
5	131677085	SLC22A4	rs270607†	a	g	intron	0.30	−0.063	2.0 × 10⁻⁸	0.24	−0.065	.005
5	131806615	SLC22A5-IRF1	rs6874639†	a	g	intergenic	0.19	−0.128	4.3 × 10⁻²⁰	0.32	−0.0273	.29
20	42475778	HNF4A	rs1800961	c	t	coding-nonsynon	0.03	−0.124	4.5 × 10⁻⁶	0.006	−0.098	.38

Chromosome	Coordinate	Gene	SNP	Allele 1	Allele 2	Variant type	EAs			AAs
Chromosome	Coordinate	Gene	SNP	Allele 1	Allele 2	Variant type	CAF*	β	P	CAF*	β	P
1	152687402	IL6R	rs7529229	t	c	intron	0.41	−0.050	8.3 × 10⁻⁸	0.64	−0.012	.51
1	152685503	IL6R	rs8192284	a	c	coding-nonsynon	0.40	−0.046	9.3 × 10⁻⁷	0.14	−0.060	.02
1	245670086	NLRP3	rs4925659	g	a	intron	0.38	0.052	5.3 × 10⁻⁸	0.17	0.018	.44
1	245668218	NLRP3	rs12239046	c	t	intron	0.39	−0.049	3.3 × 10⁻⁷	0.49	−0.039	.02
2	113588522	IL1RN	rs315921	g	a	5′ upstream	0.18	−0.057	2.6 × 10⁻⁶	0.03	0.030	.54
2	113590938	IL1RN	rs4251961	t	c	5′ upstream	0.38	0.040	2.1 × 10⁻⁵	0.18	0.097	1.8 × 10⁻⁵
2	211248752	CPS1	rs7422339	c	a	coding-nonsynon	0.32	−0.060	1.9 × 10⁻⁹	0.37	−0.021	.25
2	241877453	HDLBP	rs6752050	t	c	untranslated	0.15	−0.063	1.2 × 10⁻⁶	0.03	−0.033	.51
3	137485499	PCCB	rs3821445	a	g	intron	0.20	0.056	1.2 × 10⁻⁶	0.11	−0.005	.85
4	155703465	FGB	rs1800787	c	t	5′ upstream	0.21	0.151	1.4 × 10⁻³⁹	0.10	0.146	4.7 × 10⁻⁷
4	155709058	FGB	rs6054	c	t	coding-nonsynon	0.004	−0.580	1.2 × 10⁻¹⁷	0.001	−0.343	.14
4	155746886	FGG	rs2066861	c	t	5′ upstream	0.23	−0.068	4.2 × 10⁻¹⁰	0.29	−0.073	6.8 × 10⁻⁵
4	155749031	FGG	rs2066874	t	c	intron	8 × 10⁻⁵	−0.289	.62	0.03	−0.333	2.9 × 10⁻¹¹
4	155734845	FGA	rs10050257	t	g	5′ upstream	0.0009	−0.288	.10	0.06	−0.213	7.7 × 10⁻⁹
4	155729726	FGA	rs2070017	c	t	intron	0.002	−0.303	.03	0.11	−0.163	4.8 × 10⁻⁹
4	155709794	FGB	rs6058	g	t	coding-synon	0.0001	−0.676	.02	0.07	−0.170	9.5 × 10⁻⁷
4	155740078	FGA-FGG	rs10034922†	c	t	intergenic	0.01	0.115	.09	0.19	−0.121	3.9 × 10⁻⁷
5	131677085	SLC22A4	rs270607†	a	g	intron	0.30	−0.063	2.0 × 10⁻⁸	0.24	−0.065	.005
5	131806615	SLC22A5-IRF1	rs6874639†	a	g	intergenic	0.19	−0.128	4.3 × 10⁻²⁰	0.32	−0.0273	.29
20	42475778	HNF4A	rs1800961	c	t	coding-nonsynon	0.03	−0.124	4.5 × 10⁻⁶	0.006	−0.098	.38

Coded allele frequency of allele 2.

†

SNP genotype imputed from HapMap CEU or CEU plus YRI.

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