HCMV VR1814-induced and -repressed secretome factors* in infected HUVECs
| Protein . | Mock secretome average intensity ± SD . | Infected secretome average intensity ± SD . | Fold change . | P . |
|---|---|---|---|---|
| RANTES | 1591 ± 215 | 48982 ± 659 | 30.8 | .0000 |
| MCP-2 | 1625 ± 186 | 24136 ± 5777 | 14.8 | .0004 |
| I-309 | 90 ± 13 | 1150 ± 352 | 12.8 | .0020 |
| MIP-3α | 5815 ± 369 | 47202 ± 6571 | 8.1 | .0000 |
| IL-6 | 6769 ± 395 | 43424 ± 4339 | 6.4 | .0000 |
| IP-10 | 1261 ± 118 | 7451 ± 630 | 5.9 | .0000 |
| GCP-2 | 1471 ± 88 | 6824 ± 1301 | 4.6 | .0002 |
| MIP-1β | 982 ± 42 | 3580 ± 947 | 3.6 | .0043 |
| MCP-3 | 8184 ± 963 | 28152 ± 3962 | 3.4 | .0001 |
| MPIF-1 | 5812 ± 602 | 19259 ± 1094 | 3.3 | .0000 |
| GM-CSF | 1422 ± 102 | 4384 ± 507 | 3.1 | .0000 |
| I-TAC | 2436 ± 219 | 7626 ± 996 | 3.1 | .0003 |
| Osteoprotegerin | 179 ± 34 | 555 ± 106 | 3.1 | .0030 |
| ICAM-1 | 544 ± 28 | 1636 ± 209 | 3.0 | .0001 |
| GRO-α | 1443 ± 149 | 3985 ± 354 | 2.8 | .0001 |
| MMP-9 | 17 ± 8 | 43 ± 6 | 2.5 | .0167 |
| MIP-1α | 1680 ± 139 | 4045 ± 640 | 2.4 | .0005 |
| Sglec5 | 123 ± 56 | 295 ± 53 | 2.4 | .0390 |
| TIMP4 | 110 ± 49 | 218 ± 34 | 2.0 | .0155 |
| Axl | 779 ± 120 | 1648 ± 351 | 2.1 | .0171 |
| PDGF AA | 10368 ± 1215 | 19024 ± 4668 | 1.8 | .0278 |
| IL-8 | 865 ± 63 | 1507 ± 112 | 1.7 | .0019 |
| CD14 | 535 ± 85 | 883 ± 44 | 1.6 | .0030 |
| EGF | 1375 ± 89 | 2246 ± 425 | 1.6 | .0179 |
| CXCL16 | 2075 ± 65 | 3365 ± 660 | 1.6 | .0418 |
| TNFα | 1309 ± 99 | 1923 ± 157 | 1.5 | .0025 |
| VE-cadherin | 82 ± 3 | 125 ± 14 | 1.5 | .0050 |
| PDGF AB | 3396 ± 275 | 4703 ± 588 | 1.4 | .0066 |
| b-NGF | 307 ± 56 | 332 ± 12 | 1.1 | .0390 |
| MIF | 2280 ± 283 | 1423 ± 228 | 0.62 | .0019 |
| Tie-1 | 470 ± 73 | 223 ± 36 | 0.47 | .0019 |
| Endoglin | 1053 ± 208 | 463 ± 107 | 0.44 | .0024 |
| TRAIL R3 | 3134 ± 195 | 848 ± 13 | 0.27 | .0000 |
| TECK | 133 ± 10 | 22 ± 13 | 0.16 | .0000 |
| PECAM-1 | 2470 ± 82 | 354 ± 13 | 0.15 | .0000 |
| Protein . | Mock secretome average intensity ± SD . | Infected secretome average intensity ± SD . | Fold change . | P . |
|---|---|---|---|---|
| RANTES | 1591 ± 215 | 48982 ± 659 | 30.8 | .0000 |
| MCP-2 | 1625 ± 186 | 24136 ± 5777 | 14.8 | .0004 |
| I-309 | 90 ± 13 | 1150 ± 352 | 12.8 | .0020 |
| MIP-3α | 5815 ± 369 | 47202 ± 6571 | 8.1 | .0000 |
| IL-6 | 6769 ± 395 | 43424 ± 4339 | 6.4 | .0000 |
| IP-10 | 1261 ± 118 | 7451 ± 630 | 5.9 | .0000 |
| GCP-2 | 1471 ± 88 | 6824 ± 1301 | 4.6 | .0002 |
| MIP-1β | 982 ± 42 | 3580 ± 947 | 3.6 | .0043 |
| MCP-3 | 8184 ± 963 | 28152 ± 3962 | 3.4 | .0001 |
| MPIF-1 | 5812 ± 602 | 19259 ± 1094 | 3.3 | .0000 |
| GM-CSF | 1422 ± 102 | 4384 ± 507 | 3.1 | .0000 |
| I-TAC | 2436 ± 219 | 7626 ± 996 | 3.1 | .0003 |
| Osteoprotegerin | 179 ± 34 | 555 ± 106 | 3.1 | .0030 |
| ICAM-1 | 544 ± 28 | 1636 ± 209 | 3.0 | .0001 |
| GRO-α | 1443 ± 149 | 3985 ± 354 | 2.8 | .0001 |
| MMP-9 | 17 ± 8 | 43 ± 6 | 2.5 | .0167 |
| MIP-1α | 1680 ± 139 | 4045 ± 640 | 2.4 | .0005 |
| Sglec5 | 123 ± 56 | 295 ± 53 | 2.4 | .0390 |
| TIMP4 | 110 ± 49 | 218 ± 34 | 2.0 | .0155 |
| Axl | 779 ± 120 | 1648 ± 351 | 2.1 | .0171 |
| PDGF AA | 10368 ± 1215 | 19024 ± 4668 | 1.8 | .0278 |
| IL-8 | 865 ± 63 | 1507 ± 112 | 1.7 | .0019 |
| CD14 | 535 ± 85 | 883 ± 44 | 1.6 | .0030 |
| EGF | 1375 ± 89 | 2246 ± 425 | 1.6 | .0179 |
| CXCL16 | 2075 ± 65 | 3365 ± 660 | 1.6 | .0418 |
| TNFα | 1309 ± 99 | 1923 ± 157 | 1.5 | .0025 |
| VE-cadherin | 82 ± 3 | 125 ± 14 | 1.5 | .0050 |
| PDGF AB | 3396 ± 275 | 4703 ± 588 | 1.4 | .0066 |
| b-NGF | 307 ± 56 | 332 ± 12 | 1.1 | .0390 |
| MIF | 2280 ± 283 | 1423 ± 228 | 0.62 | .0019 |
| Tie-1 | 470 ± 73 | 223 ± 36 | 0.47 | .0019 |
| Endoglin | 1053 ± 208 | 463 ± 107 | 0.44 | .0024 |
| TRAIL R3 | 3134 ± 195 | 848 ± 13 | 0.27 | .0000 |
| TECK | 133 ± 10 | 22 ± 13 | 0.16 | .0000 |
| PECAM-1 | 2470 ± 82 | 354 ± 13 | 0.15 | .0000 |
Factor values (in arbitrary units) were determined by RayBiotech protein array analysis. Averages ± SD are shown from mock and infected intensity values.