Transplantation-related toxicity and mortality comparison
| Reference . | No. of patients in study . | Deaths, n (%) . | Stomatitis, n (%) . | Gut, n (%) . | Hepatic, n (%) . | Pulmonary, n (%) . | Cardiac, n (%) . | Renal, n (%) . | 1-year NRM, % . |
|---|---|---|---|---|---|---|---|---|---|
| Giralt (2001)16 | 78 | 3 (4) | 0 | 0 | 5 (6) | 5 (6) | 2 (3) | 7 (9) | 44.7* |
| Giralt (2002)49 | 22 | 1 (5) | 0 | 0 | 1 (5) | 1 (5) | 1 (5) | 1 (5) | 40 ± 10 |
| Ritchie (2003)45 | 39 | 4 (10) | 2 (5) | 0 | 2 (5) | 4 (10) | 1 (3) | 3 (8) | 30 ± 7 |
| de Lima (2004)44 | 62 | 6 (10) | 1 (2) | 4 (6) | 1 (2) | 9 (14) | 4 (6) | 3 (5) | 30 |
| Current study | 33 | 0 | 0 | 3 (10) | 1 (3) | 5 (15) | 1 (3) | 3 (10) | 19 ± 7 |
| Reference . | No. of patients in study . | Deaths, n (%) . | Stomatitis, n (%) . | Gut, n (%) . | Hepatic, n (%) . | Pulmonary, n (%) . | Cardiac, n (%) . | Renal, n (%) . | 1-year NRM, % . |
|---|---|---|---|---|---|---|---|---|---|
| Giralt (2001)16 | 78 | 3 (4) | 0 | 0 | 5 (6) | 5 (6) | 2 (3) | 7 (9) | 44.7* |
| Giralt (2002)49 | 22 | 1 (5) | 0 | 0 | 1 (5) | 1 (5) | 1 (5) | 1 (5) | 40 ± 10 |
| Ritchie (2003)45 | 39 | 4 (10) | 2 (5) | 0 | 2 (5) | 4 (10) | 1 (3) | 3 (8) | 30 ± 7 |
| de Lima (2004)44 | 62 | 6 (10) | 1 (2) | 4 (6) | 1 (2) | 9 (14) | 4 (6) | 3 (5) | 30 |
| Current study | 33 | 0 | 0 | 3 (10) | 1 (3) | 5 (15) | 1 (3) | 3 (10) | 19 ± 7 |
All toxicities listed use the Bearman scale27 and show grade III and IV (lethal) toxicities before day 100. Studies listed used FLU/MEL conditioning regimens. n = number of events of each toxicity; and % = n divided by the number of patients on the study multiplied by 100.
For Giralt (2001),16 NRM not given at 1 year. At 2 years, 44.7%; at 100 days, 37.4%.