Demographic, clinical, and laboratory data for DIC patients and controls
| . | DIC patients . | Thrombocytopenia controls . | Healthy controls . | P . |
|---|---|---|---|---|
| n | 29 | 36 | 25 | |
| Age, y | 61.8 ± 18.2 | 54.0 ± 15.8 | 35.8 ± 8.6 | < .0001 |
| Sex (male), % | 41.3 | 52.7 | 36.0 | .40 |
| Platelet count, × 103/μL | 67.3 ± 62.8 | 26.8 ± 10.7 | 396.8 ± 100.8 | < .0001 |
| Cause, % | ||||
| Sepsis | 44.8 | 0 | NA | < .0001 |
| Hematologic malignancy | 20.6 | 83.3 | NA | < .0001 |
| Solid tumor | 24.1 | 13.9 | NA | .30 |
| Others | 17.2 | 2.8 | NA | .048 |
| Coagulation markers | ||||
| APTT (reference range, 28-40 sec) | 52.6 ± 40.1 | 31.2 ± 4.2 | NA | .002 |
| INR (reference range, 0.9-1.2) | 1.9 ± 1.3 | 1.0 ± 0.2 | NA | < .0001 |
| Fibrinogen (reference range, 2-4 g/L) | 2.0 ± 1.6 | 4.7 ± 2.3 | NA | < .0001 |
| D-dimer (reference range, 0.0-0.5 μg/mL)* | ||||
| Thrombotic events | 2/29 | 0/36 | 0/25 | .18 |
| sGPVI, ng/mL; mean (95% CI)† | 53.9 (39.9-72.8) | 12.5 (9.0-17.3) | 14.6 (7.9-27.0) | < .0001 |
| sGPVI, ng/mL; mean (95% CI)‡ | 41.9 (30.2-58.1) | 14.9 (11.0-20.2) | NA | < .0001 |
| . | DIC patients . | Thrombocytopenia controls . | Healthy controls . | P . |
|---|---|---|---|---|
| n | 29 | 36 | 25 | |
| Age, y | 61.8 ± 18.2 | 54.0 ± 15.8 | 35.8 ± 8.6 | < .0001 |
| Sex (male), % | 41.3 | 52.7 | 36.0 | .40 |
| Platelet count, × 103/μL | 67.3 ± 62.8 | 26.8 ± 10.7 | 396.8 ± 100.8 | < .0001 |
| Cause, % | ||||
| Sepsis | 44.8 | 0 | NA | < .0001 |
| Hematologic malignancy | 20.6 | 83.3 | NA | < .0001 |
| Solid tumor | 24.1 | 13.9 | NA | .30 |
| Others | 17.2 | 2.8 | NA | .048 |
| Coagulation markers | ||||
| APTT (reference range, 28-40 sec) | 52.6 ± 40.1 | 31.2 ± 4.2 | NA | .002 |
| INR (reference range, 0.9-1.2) | 1.9 ± 1.3 | 1.0 ± 0.2 | NA | < .0001 |
| Fibrinogen (reference range, 2-4 g/L) | 2.0 ± 1.6 | 4.7 ± 2.3 | NA | < .0001 |
| D-dimer (reference range, 0.0-0.5 μg/mL)* | ||||
| Thrombotic events | 2/29 | 0/36 | 0/25 | .18 |
| sGPVI, ng/mL; mean (95% CI)† | 53.9 (39.9-72.8) | 12.5 (9.0-17.3) | 14.6 (7.9-27.0) | < .0001 |
| sGPVI, ng/mL; mean (95% CI)‡ | 41.9 (30.2-58.1) | 14.9 (11.0-20.2) | NA | < .0001 |
Data are mean ± SD.
DIC indicates disseminated intravascular coagulation; APTT, activated partial thromboplastin time; INR, international normalized ratio; sGPVI, soluble glycoprotein VI; CI, confidence interval; and NA, not applicable.
All DIC cases were positive for D-dimer (> 0.5 μg/mL), with 20 of 29 cases > 10 μg/mL (upper sensitivity limit of the assay).
sGPVI levels are adjusted for age and platelet count only.
sGPVI levels are adjusted for age, platelet count, underlying cause, and coagulation markers.