Examples of historical differences between adult and pediatric ALL protocols
| Component . | Difference . |
|---|---|
| Non-myelosuppressive drugs (glucorticoids, vincristine, L-asparaginase) | Greater amounts in pediatric protocols |
| CNS prophylaxis | Earlier and with greater frequency in pediatric protocols |
| Long-term maintenance therapy | Longer duration in pediatric protocols |
| Component . | Difference . |
|---|---|
| Non-myelosuppressive drugs (glucorticoids, vincristine, L-asparaginase) | Greater amounts in pediatric protocols |
| CNS prophylaxis | Earlier and with greater frequency in pediatric protocols |
| Long-term maintenance therapy | Longer duration in pediatric protocols |
CNS indicates central nervous system.