Cytogenetic results and treatment responses of 30 patients with variant translocations
| Case . | Sex . | Karyotype at diagnosis . | Der(9) deletion . | FISH pattern . | Mechanism . | CgR at 12 mo . | CgR at last contact . |
|---|---|---|---|---|---|---|---|
| 1 | F | 46,XX,t(3;9;22)(q27;q34;q11) | 1F2R2G | 1-step | CCgR | CCgR | |
| 2 | F | 46,XX,t(5;9:22)(q13;q34;q11) | 1F2R2G | 1-step | CCgR | CCgR | |
| 3 | M | 46,XY,t(5;9;22;17)(q12;q34;q11;q11) | 1F2R2G | 1-step | CCgR | CCgR | |
| 4 | M | 46,XY,t(8;9;22)(q21;q34;q11) | 1F2R2G | 1-step | CCgR | CCgR | |
| 5 | F | 46,XX,t(8,9,22)(q22;q34;q11) | 1F2R2G | 1-step | CCgR | CCgR | |
| 6 | M | 46,XY,t(9;9;22)(p13;q34;q22) | 1F2R2G | 1-step | Dropout | Death | |
| 7 | M | 46,XY,t(9;22;10)(q34;q11;q21) | 1F2R2G | 1-step | CCgR | CCgR | |
| 8 | F | 46,XX,t(9;22;11)(q34;q11;q13) | 1F2R2G | 1-step | CCgR | CCgR | |
| 9 | M | 46,XY,t(9;22;11)(q34;q11;q13) | 1F2R2G | 1-step | CCgR | CCgR | |
| 10 | M | 46,XY,t(9;22;12)(q34;q11;q24) | 1F2R2G | 1-step | CCgR | CCgR | |
| 11 | M | 46,XY,t(9;22;14)(q34;q11;q32) | 1F2R2G | 1-step | NE | CCgR | |
| 12 | M | 46,XY,t(9;22;15)(q34;q11;q22) | 1F2R2G | 1-step | Dropout | Death | |
| 13 | M | 46,XY,t(9;22;15)(q34;q11;q21) | 1F2R2G | 1-step | Failure | Failure | |
| 14 | M | 46,XY,t(9;22;17)(q34;q11;p13) | 1F2R2G | 1-step | CCgR | CCgR | |
| 15 | M | 46,XY,t(9;22;17)(q34;q11;q21) | 1F2R2G | 1-step | PCgR | CCgR | |
| 16 | F | 46,XX,t(9;22;19)(q34;q11;p13) | 1F2R2G | 1-step | CCgR | CCgR | |
| 17 | M | 46,XY,t(9;9;22)(q34;q34;q11) | 2F1R1G | 2-step | CCgR | Failure | |
| 18 | F | 46,XX,t(9;22;16)(q34;q11;p12) | 2F1R1G | 2-step | CCgR | CCgR | |
| 19 | F | 46,XX,t(9;22;22)(q34;q11;q11), t(7;19)(q21;p13) | 2F1R | 1-step | CCgR | CCgR | |
| 20 | M | 46,XY,t(9;22;11)(q34;q11;q13) | BCR on 3rd chromosome | 1F2R1G | 2-step | CCgR | CCgR |
| 21 | F | 46,XX,t(9;22;15)(q34;q11;q15) | BCR on 3rd chromosome | 1F2R1G | 1-step | CCgR | Death |
| 22 | M | 46,XY,t(1;9;22)(q21;q34;q11) Ph masked | 1F2R1G | Multistep | Failure | Failure | |
| 23 | M | 46,XY,t(9;22;12)(q34;q11;q24) | ABL1/BCR on 3rd chromosome | 1F1R1G | 2-step | NE | CCgR |
| 24 | F | 46,XX,t(9;9;22)(p13;q34;q22) | ABL1 | 1F1R1G | Multistep | PCgR | CCgR |
| 25 | M | 46,XY,t(1;9;22)(?;q34;q11) | NE | NE | CCgR | CCgR | |
| 26 | F | 46,XX,t(1;9;22)(?;q34;q11) | ABL1 | NE | NE | Failure | Failure |
| 27 | F | 46,XX,t(9;22;12)(q34;q11;?) | NE | NE | CCgR | CCgR | |
| 28 | M | 46,XY,t(3;9;22)(p21;q34;q11) | ABL1 | NE | NE | CCgR | CCgR |
| 29 | M | 46,XY,t(9;22;16;17)(q34;q11;?;?) | NE | NE | CCgR | CCgR | |
| 30 | M | 46,XY,t(9;22;21)(q34;q11;?) | NE | NE | CCgR | CCgR |
| Case . | Sex . | Karyotype at diagnosis . | Der(9) deletion . | FISH pattern . | Mechanism . | CgR at 12 mo . | CgR at last contact . |
|---|---|---|---|---|---|---|---|
| 1 | F | 46,XX,t(3;9;22)(q27;q34;q11) | 1F2R2G | 1-step | CCgR | CCgR | |
| 2 | F | 46,XX,t(5;9:22)(q13;q34;q11) | 1F2R2G | 1-step | CCgR | CCgR | |
| 3 | M | 46,XY,t(5;9;22;17)(q12;q34;q11;q11) | 1F2R2G | 1-step | CCgR | CCgR | |
| 4 | M | 46,XY,t(8;9;22)(q21;q34;q11) | 1F2R2G | 1-step | CCgR | CCgR | |
| 5 | F | 46,XX,t(8,9,22)(q22;q34;q11) | 1F2R2G | 1-step | CCgR | CCgR | |
| 6 | M | 46,XY,t(9;9;22)(p13;q34;q22) | 1F2R2G | 1-step | Dropout | Death | |
| 7 | M | 46,XY,t(9;22;10)(q34;q11;q21) | 1F2R2G | 1-step | CCgR | CCgR | |
| 8 | F | 46,XX,t(9;22;11)(q34;q11;q13) | 1F2R2G | 1-step | CCgR | CCgR | |
| 9 | M | 46,XY,t(9;22;11)(q34;q11;q13) | 1F2R2G | 1-step | CCgR | CCgR | |
| 10 | M | 46,XY,t(9;22;12)(q34;q11;q24) | 1F2R2G | 1-step | CCgR | CCgR | |
| 11 | M | 46,XY,t(9;22;14)(q34;q11;q32) | 1F2R2G | 1-step | NE | CCgR | |
| 12 | M | 46,XY,t(9;22;15)(q34;q11;q22) | 1F2R2G | 1-step | Dropout | Death | |
| 13 | M | 46,XY,t(9;22;15)(q34;q11;q21) | 1F2R2G | 1-step | Failure | Failure | |
| 14 | M | 46,XY,t(9;22;17)(q34;q11;p13) | 1F2R2G | 1-step | CCgR | CCgR | |
| 15 | M | 46,XY,t(9;22;17)(q34;q11;q21) | 1F2R2G | 1-step | PCgR | CCgR | |
| 16 | F | 46,XX,t(9;22;19)(q34;q11;p13) | 1F2R2G | 1-step | CCgR | CCgR | |
| 17 | M | 46,XY,t(9;9;22)(q34;q34;q11) | 2F1R1G | 2-step | CCgR | Failure | |
| 18 | F | 46,XX,t(9;22;16)(q34;q11;p12) | 2F1R1G | 2-step | CCgR | CCgR | |
| 19 | F | 46,XX,t(9;22;22)(q34;q11;q11), t(7;19)(q21;p13) | 2F1R | 1-step | CCgR | CCgR | |
| 20 | M | 46,XY,t(9;22;11)(q34;q11;q13) | BCR on 3rd chromosome | 1F2R1G | 2-step | CCgR | CCgR |
| 21 | F | 46,XX,t(9;22;15)(q34;q11;q15) | BCR on 3rd chromosome | 1F2R1G | 1-step | CCgR | Death |
| 22 | M | 46,XY,t(1;9;22)(q21;q34;q11) Ph masked | 1F2R1G | Multistep | Failure | Failure | |
| 23 | M | 46,XY,t(9;22;12)(q34;q11;q24) | ABL1/BCR on 3rd chromosome | 1F1R1G | 2-step | NE | CCgR |
| 24 | F | 46,XX,t(9;9;22)(p13;q34;q22) | ABL1 | 1F1R1G | Multistep | PCgR | CCgR |
| 25 | M | 46,XY,t(1;9;22)(?;q34;q11) | NE | NE | CCgR | CCgR | |
| 26 | F | 46,XX,t(1;9;22)(?;q34;q11) | ABL1 | NE | NE | Failure | Failure |
| 27 | F | 46,XX,t(9;22;12)(q34;q11;?) | NE | NE | CCgR | CCgR | |
| 28 | M | 46,XY,t(3;9;22)(p21;q34;q11) | ABL1 | NE | NE | CCgR | CCgR |
| 29 | M | 46,XY,t(9;22;16;17)(q34;q11;?;?) | NE | NE | CCgR | CCgR | |
| 30 | M | 46,XY,t(9;22;21)(q34;q11;?) | NE | NE | CCgR | CCgR |
In the FISH patterns, R indicates red signal; G, green signal; and F, fusion signal.
NE indicates not evaluable; failure was according to the definition by the 2009 European LeukemiaNet recommendations; and dropout, IM permanent discontinuation for any reason other than failure.