Standardized incidence ratios and absolute excess risks of cardiovascular disease after NHL treatment including radiotherapy: a cumulative dose-risk relation
Event, radiation dose . | No. of patients* . | No. observed . | No. expected . | SIR (95% CI) . | AER per 10 000 person-years . |
|---|---|---|---|---|---|
| Chronic heart failure | |||||
| No radiotherapy on mediastinum | 311 | 39 | 8.9 | 4.4 (3.1-6.0) | 167 |
| 30 Gy or less | 30 | 5 | 1.1 | 4.7 (1.0-8.2) | 171 |
| 30-40 Gy | 85 | 11 | 1.6 | 6.8 (3.3-13.3) | 232 |
| More than 40 Gy | 15 | 9 | 0.3 | 32.0 (13.7-57) | 932 |
| Myocardial infarction | |||||
| No radiotherapy on mediastinum | 337 | 10 | 11.6 | 0.9 (0.4-1.6) | –8 |
| 30 Gy or less | 32 | 1 | 1.3 | 0.8 (0.3-2.3) | 1 |
| 30-40 Gy | 89 | 3 | 2.1 | 1.4 (0.4-4.3) | 5 |
| More than 40 Gy | 18 | 3 | 0.4 | 7.5 (1.4-19.9) | 274 |
| Stroke | |||||
| No radiotherapy | 273 | 3 | 4.8 | 0.6 (0.1-1.2) | –12 |
| 30 Gy or less | 48 | 1 | 1.4 | 0.7 (0.1-2.7) | –9 |
| 30-40 Gy | 103 | 2 | 0.9 | 2.2 (0.1-3.1) | 5 |
| More than 40 Gy | 38 | 5 | 0.7 | 8.6 (3.1-18.7) | 260 |
Event, radiation dose . | No. of patients* . | No. observed . | No. expected . | SIR (95% CI) . | AER per 10 000 person-years . |
|---|---|---|---|---|---|
| Chronic heart failure | |||||
| No radiotherapy on mediastinum | 311 | 39 | 8.9 | 4.4 (3.1-6.0) | 167 |
| 30 Gy or less | 30 | 5 | 1.1 | 4.7 (1.0-8.2) | 171 |
| 30-40 Gy | 85 | 11 | 1.6 | 6.8 (3.3-13.3) | 232 |
| More than 40 Gy | 15 | 9 | 0.3 | 32.0 (13.7-57) | 932 |
| Myocardial infarction | |||||
| No radiotherapy on mediastinum | 337 | 10 | 11.6 | 0.9 (0.4-1.6) | –8 |
| 30 Gy or less | 32 | 1 | 1.3 | 0.8 (0.3-2.3) | 1 |
| 30-40 Gy | 89 | 3 | 2.1 | 1.4 (0.4-4.3) | 5 |
| More than 40 Gy | 18 | 3 | 0.4 | 7.5 (1.4-19.9) | 274 |
| Stroke | |||||
| No radiotherapy | 273 | 3 | 4.8 | 0.6 (0.1-1.2) | –12 |
| 30 Gy or less | 48 | 1 | 1.4 | 0.7 (0.1-2.7) | –9 |
| 30-40 Gy | 103 | 2 | 0.9 | 2.2 (0.1-3.1) | 5 |
| More than 40 Gy | 38 | 5 | 0.7 | 8.6 (3.1-18.7) | 260 |
Comparison in 476 patients for myocardial infarction (1980-2000) and in 441 patients for chronic heart failure and stroke (1985-2000)