Effect of maternal anti–β3 integrin IgG and IVIG on fetal and neonatal bleeding disorders
. | Breeding cages . | Total pups . | Dead pups . | Bleeding disorders . | Miscarriage* . |
|---|---|---|---|---|---|
| First delivery | |||||
| β3–/– × WT† | 7 | 57 | 2# | 0** | 0 |
| Immunized β3–/– × WT‡ | 8 | 54 | 13#†† | 7** | 2 |
| Immunized β3–/– × WT; IVIG§ | 2 | 12 | 0 | 0 | 0 |
| Second delivery | |||||
| Immunized β3–/– × WT; IVIG∥ | 5 | 36 | 1†† | 2‡‡ | 0 |
| Immunized β3–/– × WT albumin¶ | 2 | 16 | 1 | 4‡‡ | 0 |
. | Breeding cages . | Total pups . | Dead pups . | Bleeding disorders . | Miscarriage* . |
|---|---|---|---|---|---|
| First delivery | |||||
| β3–/– × WT† | 7 | 57 | 2# | 0** | 0 |
| Immunized β3–/– × WT‡ | 8 | 54 | 13#†† | 7** | 2 |
| Immunized β3–/– × WT; IVIG§ | 2 | 12 | 0 | 0 | 0 |
| Second delivery | |||||
| Immunized β3–/– × WT; IVIG∥ | 5 | 36 | 1†† | 2‡‡ | 0 |
| Immunized β3–/– × WT albumin¶ | 2 | 16 | 1 | 4‡‡ | 0 |
Underlined value indicates that statistically significant difference was also observed compared with the immunized but IVIG-untreated group in the first delivery (χ2 > 4.13; P < .05).
Female β3–/– mice delivered immature dead pups
Naive female β3–/– mice (without immunization with WT platelets) were bred with WT male mice
Female β3–/– mice; first delivery after two times immunization with WT platelets
Female β3–/– mice were transfused with IVIG during first delivery
Female β3–/– mice were transfused with IVIG during second delivery
Female β3–/– mice were transfused with albumin as a control during second delivery
P < .005. This and the following three footnotes indicate P values for comparisons of the two values in the table sharing that footnote
P < .005
P < .05
P < .05