Distribution of polymorphism Arg407Lys and association with α2AP levels and plasma clot lysis times
| . | Patients (n = 319) . | Control individuals (n = 169) . | ||
|---|---|---|---|---|
| C-terminally cleaved α2AP, % | n | mean (95% CI) | n | mean (95% CI) |
| 407 Arg/Arg | 209 | 37.7 (36.6-38.9) | 99 | 37.8 (36.4-39.2) |
| 407 Arg/Lys | 97 | 38.5 (37.1-40.0) | 62 | 39.9 (38.0-41.9) |
| 407 Lys/Lys | 13 | 39.6 (35.3-43.8) | 8 | 38.7 (33.3-44.0) |
| P = .575 | P = .205 | |||
| Total α2AP antigen level, aU/dL | ||||
| 407 Arg/Arg | 209 | 93.6 (91.4-95.9) | 99 | 110.0 (106.6-113.4) |
| 407 Arg/Lys | 97 | 94.0 (91.1-97.0) | 62 | 112.9 (108.8-116.9) |
| 407 Lys/Lys | 13 | 94.4 (95.9-102.9) | 8 | 99.9 (83.5-116.3) |
| P = .969 | P = .105 | |||
| C-terminally intact α2AP antigen level, aU/dL | ||||
| 407 Arg/Arg | 209 | 57.3 (56.4-58.3) | 99 | 67.8 (66.0-69.7) |
| 407 Arg/Lys | 97 | 57.0 (55.9-58.1) | 62 | 67.3 (64.8-69.8) |
| 407 Lys/Lys | 13 | 56.5 (52.6-60.3) | 8 | 60.7 (52.7-68.7) |
| P = .851 | P = .129 | |||
| Plasma clot lysis time, min | ||||
| 407 Arg/Arg | - | 87 | 10.0 (9.4-10.6) | |
| 407 Arg/Lys | - | 57 | 10.3 (9.4-11.2) | |
| 407 Lys/Lys | - | 8 | 8.7 (7.3-10.1) | |
| P = .355 | ||||
| . | Patients (n = 319) . | Control individuals (n = 169) . | ||
|---|---|---|---|---|
| C-terminally cleaved α2AP, % | n | mean (95% CI) | n | mean (95% CI) |
| 407 Arg/Arg | 209 | 37.7 (36.6-38.9) | 99 | 37.8 (36.4-39.2) |
| 407 Arg/Lys | 97 | 38.5 (37.1-40.0) | 62 | 39.9 (38.0-41.9) |
| 407 Lys/Lys | 13 | 39.6 (35.3-43.8) | 8 | 38.7 (33.3-44.0) |
| P = .575 | P = .205 | |||
| Total α2AP antigen level, aU/dL | ||||
| 407 Arg/Arg | 209 | 93.6 (91.4-95.9) | 99 | 110.0 (106.6-113.4) |
| 407 Arg/Lys | 97 | 94.0 (91.1-97.0) | 62 | 112.9 (108.8-116.9) |
| 407 Lys/Lys | 13 | 94.4 (95.9-102.9) | 8 | 99.9 (83.5-116.3) |
| P = .969 | P = .105 | |||
| C-terminally intact α2AP antigen level, aU/dL | ||||
| 407 Arg/Arg | 209 | 57.3 (56.4-58.3) | 99 | 67.8 (66.0-69.7) |
| 407 Arg/Lys | 97 | 57.0 (55.9-58.1) | 62 | 67.3 (64.8-69.8) |
| 407 Lys/Lys | 13 | 56.5 (52.6-60.3) | 8 | 60.7 (52.7-68.7) |
| P = .851 | P = .129 | |||
| Plasma clot lysis time, min | ||||
| 407 Arg/Arg | - | 87 | 10.0 (9.4-10.6) | |
| 407 Arg/Lys | - | 57 | 10.3 (9.4-11.2) | |
| 407 Lys/Lys | - | 8 | 8.7 (7.3-10.1) | |
| P = .355 | ||||
CI indicates confidence interval.