Old and new WHO classifications of PTCLs
| Old WHO classification7 . | New WHO classification9 . |
|---|---|
| Precursor T-cell lymphoma | |
| T-lymphoblastic lymphoma/leukemia | |
| Mature T-cell lymphomas | |
| T-cell prolymphocytic leukemia | T-cell prolymphocytic leukemia |
| T-cell granular lymphocytic leukemia | T-cell large granular lymphocytic leukemia |
| Aggressive NK-cell leukemia | Aggressive NK-cell leukemia |
| Indolent large granular NK-cell lymphoproliferative disorder (provisional) | |
| ATL/adult T-cell leukemia (HTLV1+) | ATL/adult T-cell leukemia |
| Extranodal NK-/T-cell lymphoma, nasal type | Extranodal NK-/T-cell lymphoma, nasal type |
| Enteropathy-type T-cell lymphoma | EATL |
| Hepatosplenanic T-cell lymphoma | Hepatosplenic T-cell lymphoma |
| Subcutaneous panniculitis-like T-cell lymphoma | Subcutaneous panniculitis-like T-cell lymphoma (αβ only) |
| Primary cutaneous γδ T-cell lymphoma | |
| Mycosis fungoides/Sézary syndrome | Mycosis fungoides/Sézary syndrome |
| Anaplastic large-cell lymphoma, systemic or cutaneous | ALCL: ALK+ |
| ALCL: ALK− (provisional) | |
| PTCL, unspecified | PTCL, NOS |
| AITL | AITL |
| Primary cutaneous CD30+ T-cell LPD | |
| LYP and primary cutaneous ALCL | |
| Primary cutaneous CD4+ small/medium T-cell lymphoma (provisional) | |
| Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma (provisional) | |
| Systemic EBV+ T-cell LPD of childhood | |
| Hydroa vacciniforme-like lymphoma |
| Old WHO classification7 . | New WHO classification9 . |
|---|---|
| Precursor T-cell lymphoma | |
| T-lymphoblastic lymphoma/leukemia | |
| Mature T-cell lymphomas | |
| T-cell prolymphocytic leukemia | T-cell prolymphocytic leukemia |
| T-cell granular lymphocytic leukemia | T-cell large granular lymphocytic leukemia |
| Aggressive NK-cell leukemia | Aggressive NK-cell leukemia |
| Indolent large granular NK-cell lymphoproliferative disorder (provisional) | |
| ATL/adult T-cell leukemia (HTLV1+) | ATL/adult T-cell leukemia |
| Extranodal NK-/T-cell lymphoma, nasal type | Extranodal NK-/T-cell lymphoma, nasal type |
| Enteropathy-type T-cell lymphoma | EATL |
| Hepatosplenanic T-cell lymphoma | Hepatosplenic T-cell lymphoma |
| Subcutaneous panniculitis-like T-cell lymphoma | Subcutaneous panniculitis-like T-cell lymphoma (αβ only) |
| Primary cutaneous γδ T-cell lymphoma | |
| Mycosis fungoides/Sézary syndrome | Mycosis fungoides/Sézary syndrome |
| Anaplastic large-cell lymphoma, systemic or cutaneous | ALCL: ALK+ |
| ALCL: ALK− (provisional) | |
| PTCL, unspecified | PTCL, NOS |
| AITL | AITL |
| Primary cutaneous CD30+ T-cell LPD | |
| LYP and primary cutaneous ALCL | |
| Primary cutaneous CD4+ small/medium T-cell lymphoma (provisional) | |
| Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma (provisional) | |
| Systemic EBV+ T-cell LPD of childhood | |
| Hydroa vacciniforme-like lymphoma |
The WHO classification for PTCLs was updated in 2008. The new classification expanded some existing disease types and added several new provisional diseases.
WHO indicates World Health Organization; PTCL, peripheral T-cell lymphoma; NK, natural killer; HTLV1, human T-lymphotropic virus type 1; EATL, enteropathy-associated T-cell lymphoma; and ALCL, anaplastic large cell lymphoma; AITL, angioimmunoblastic T-cell lymphoma; and NOS, not otherwise specified.