Table 2

Hemoglobin concentration, blood cell counts, mean platelet volume, and serum TPO level of patients with ANKRD26 mutations

Parameter (no. of investigated patients)Patients, mean (SD), no. of cases with values higher/lower than the normal rangeHealthy subjects, mean (normal range)One sample t test vs mean value of healthy subjects, P (P vs upper/lower reference limit)
Hemoglobin, g/dL    
    Male (n = 40) 15.4 (1.9), 4/7 15.7 (14.0-17.5)* .32 
    Female (n = 38) 13.5 (1.4), 5/4 13.8 (12.3-15.3)* .19 
WBC, × 109/L (n = 78) 9.2 (2.8), 14/2 7.8 (4.4-11.3)* < .001 (1.000) 
Neutrophils, × 109/L (n = 78) 5.51 (2.3), 11/3 4.4 (1.8-7.7)* < .001 (1.000) 
Platelets, × 109/L (n = 78) 47.5 (28.3), 0/77 307 (150-400)* < .001 (< .001) 
MPV, fL (n = 71) 9.3 (1.6), 1/15 10.7 (8.0-13.4)* < .001 (1.000) 
TPO, pg/mL (n = 38) 112.9 (62.5), 29/0 14.6 (6.9-54.4)§ < .001 (< .001) 
Parameter (no. of investigated patients)Patients, mean (SD), no. of cases with values higher/lower than the normal rangeHealthy subjects, mean (normal range)One sample t test vs mean value of healthy subjects, P (P vs upper/lower reference limit)
Hemoglobin, g/dL    
    Male (n = 40) 15.4 (1.9), 4/7 15.7 (14.0-17.5)* .32 
    Female (n = 38) 13.5 (1.4), 5/4 13.8 (12.3-15.3)* .19 
WBC, × 109/L (n = 78) 9.2 (2.8), 14/2 7.8 (4.4-11.3)* < .001 (1.000) 
Neutrophils, × 109/L (n = 78) 5.51 (2.3), 11/3 4.4 (1.8-7.7)* < .001 (1.000) 
Platelets, × 109/L (n = 78) 47.5 (28.3), 0/77 307 (150-400)* < .001 (< .001) 
MPV, fL (n = 71) 9.3 (1.6), 1/15 10.7 (8.0-13.4)* < .001 (1.000) 
TPO, pg/mL (n = 38) 112.9 (62.5), 29/0 14.6 (6.9-54.4)§ < .001 (< .001) 

WBC indicates white blood cells; and MPV, mean platelet volume.

*

Reference values of hospital central laboratory.

Versus upper reference limit.

Versus lower reference limit.

§

Values obtained in 50 healthy subjects.

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