Table 2 Responses to O-FC by... | American Society of Hematology

Table 2

Responses to O-FC by pretreatment characteristics and number of treatment courses received

Characteristic	n*	CR rate, %	OR rate, %
All patients	61	41	75
Sex
Male	43	35	70
Female	18	56	89
Age, y
< 65	50	44	76
≥ 65	11	27	73
ECOG performance status
0	34	47	82
1-2	27	33	67
Palpable lymph nodes
≤ 5 cm	51	39	78
> 5 cm	10	50	60
Rai stage
0-II	33	36	73
III-IV	28	46	79
Binet stage
A	8	38	75
B	33	42	79
C	20	40	70
β-2M†
< 4 mg/L	32	53	84
≥ 4 mg/L	28	29	68
Lactate dehydrogenase†
< 228 IU/L	30	40	77
≥ 228 IU/L	31	42	74
Thymidine kinase†
< 29 IU/L	29	45	76
≥ 29 IU/L	30	40	80
ALC†
< 90 × 10⁹/L	31	45	81
≥ 90 × 10⁹/L	30	37	70
CD38 expression (%)
< 30	48	44	77
≥ 30	12	33	67
IGHV mutation status
Mutated	28	46	75
Unmutated‡	25	36	84
FISH genomic abnormalitym§
17p del	8	13	63
11q del	10	40	70
Trisomy 12q	8	63	63
No abnormality	7	71	100
13q del (sole)	25	32	80
O-FC courses received, no.
6	39	56‖	92‖
4-5	9	33	78
1-3	13	0	23

Characteristic	n*	CR rate, %	OR rate, %
All patients	61	41	75
Sex
Male	43	35	70
Female	18	56	89
Age, y
< 65	50	44	76
≥ 65	11	27	73
ECOG performance status
0	34	47	82
1-2	27	33	67
Palpable lymph nodes
≤ 5 cm	51	39	78
> 5 cm	10	50	60
Rai stage
0-II	33	36	73
III-IV	28	46	79
Binet stage
A	8	38	75
B	33	42	79
C	20	40	70
β-2M†
< 4 mg/L	32	53	84
≥ 4 mg/L	28	29	68
Lactate dehydrogenase†
< 228 IU/L	30	40	77
≥ 228 IU/L	31	42	74
Thymidine kinase†
< 29 IU/L	29	45	76
≥ 29 IU/L	30	40	80
ALC†
< 90 × 10⁹/L	31	45	81
≥ 90 × 10⁹/L	30	37	70
CD38 expression (%)
< 30	48	44	77
≥ 30	12	33	67
IGHV mutation status
Mutated	28	46	75
Unmutated‡	25	36	84
FISH genomic abnormalitym§
17p del	8	13	63
11q del	10	40	70
Trisomy 12q	8	63	63
No abnormality	7	71	100
13q del (sole)	25	32	80
O-FC courses received, no.
6	39	56‖	92‖
4-5	9	33	78
1-3	13	0	23

ALC indicates absolute lymphocyte count; and FISH, fluorescence in situ hybridization.

Patient numbers do not add up to N = 61 for some of the categories due to missing assessments.

Cutoff values were based on median levels at baseline.

Defined as ≥ 98% homology to closest germline sequence.

Based on Dohner hierarchy.²⁴

P < .05, Fisher's exact test.