Functions of crustacean astakines and vertebrate PROKs in hematopoiesis
| Feature . | Ast1 . | Ast2 . | PROK 1 . | PROK 2 . |
|---|---|---|---|---|
| Conserved N-terminal* domain | No | No | Yes | Yes |
| Receptor | Beta-subunit of ATP synthase63 | NI | PROKR1, PROKR260-62 | |
| Roles in hematopoiesis | Promotes differentiation along the SGC lineage25 and promotes survival of HPT cells by blocking the apoptotic pathway37 | Promotes differentiation along the GC lineage25 | Promotes differentiation along the monocyte/macrophage lineage51,58 | Promotes survival and differentiation of the granulocyte and monocyte lineages51,59 |
| Feature . | Ast1 . | Ast2 . | PROK 1 . | PROK 2 . |
|---|---|---|---|---|
| Conserved N-terminal* domain | No | No | Yes | Yes |
| Receptor | Beta-subunit of ATP synthase63 | NI | PROKR1, PROKR260-62 | |
| Roles in hematopoiesis | Promotes differentiation along the SGC lineage25 and promotes survival of HPT cells by blocking the apoptotic pathway37 | Promotes differentiation along the GC lineage25 | Promotes differentiation along the monocyte/macrophage lineage51,58 | Promotes survival and differentiation of the granulocyte and monocyte lineages51,59 |
GC indicates granular cells; HPT, hematopoietic tissue; NI, not identified; PROKs, prokineticins; and SGC, semigranular cells.
The amino acid sequence AVIT is conserved in vertebrate PROKs.