Table 4 Variables predictive of EFS in... | American Society of Hematology

Table 4

Variables predictive of EFS in randomized CR patients

Variable	N	Events	HR (95% CI)	P*	P†
Binet Stage
B	83	35	1
C	22	7	0.9 (0.4; 2.1)	.9
Sex
Male	69	29	1
Female	36	13	0.8 (0.4; 1.6)	.5
Age, y			0.98 (0.94; 1.03)	.4
LDH
≤ ULN	66	27	1
> ULN	30	10	1.1 (0.5; 2.2)	.9
Beta2-microglobulin
Normal	41	14	1
Abnormal	52	22	1.3 (0.7; 2.5)	.5
CD38
≤ 22	70	24	1
> 22	35	18	0.2 (0.1; 0.5)	.1
Karyotype
Normal	38	15	1
At least one abnormality	50	19	0.9 (0.5; 1.8)	.8
Translocation
No	70	25	1
Yes (balanced and imbalanced)	18	9	2.0 (0.9; 4.4)	.09
Trisomy 12
No	79	32	1
Yes	18	8	0.99 (0.5; 2.2)	1.0
Deletion (11q23)
No	80	31	1
Yes	11	8	3.8 (1.6; 8.9)	.002	.008
Deletion (13q)
No	47	27	1
Yes	45	13	0.4 (0.2; 0.7)	.004	.14
Deletion (17p13)
No	90	39	na
Yes	1	0	na
IgVH mutation
No	47	29	1
Yes	40	8	0.24 (0.11; 0.53)	.0004	.0003
ZAP 70
Negative	24	6	1
Positive	44	21	4.5 (1.7; 11.6)	.002	.49

Variable	N	Events	HR (95% CI)	P*	P†
Binet Stage
B	83	35	1
C	22	7	0.9 (0.4; 2.1)	.9
Sex
Male	69	29	1
Female	36	13	0.8 (0.4; 1.6)	.5
Age, y			0.98 (0.94; 1.03)	.4
LDH
≤ ULN	66	27	1
> ULN	30	10	1.1 (0.5; 2.2)	.9
Beta2-microglobulin
Normal	41	14	1
Abnormal	52	22	1.3 (0.7; 2.5)	.5
CD38
≤ 22	70	24	1
> 22	35	18	0.2 (0.1; 0.5)	.1
Karyotype
Normal	38	15	1
At least one abnormality	50	19	0.9 (0.5; 1.8)	.8
Translocation
No	70	25	1
Yes (balanced and imbalanced)	18	9	2.0 (0.9; 4.4)	.09
Trisomy 12
No	79	32	1
Yes	18	8	0.99 (0.5; 2.2)	1.0
Deletion (11q23)
No	80	31	1
Yes	11	8	3.8 (1.6; 8.9)	.002	.008
Deletion (13q)
No	47	27	1
Yes	45	13	0.4 (0.2; 0.7)	.004	.14
Deletion (17p13)
No	90	39	na
Yes	1	0	na
IgVH mutation
No	47	29	1
Yes	40	8	0.24 (0.11; 0.53)	.0004	.0003
ZAP 70
Negative	24	6	1
Positive	44	21	4.5 (1.7; 11.6)	.002	.49

na indicates not available.

Models adjusted on the randomization arm and stratified for the Binet stage.

Multivariate models incorporating all covariates with P values, reported, including the randomization arm, with stratification for Binet stage.