Table 5 Variables predictive of EFS in... | American Society of Hematology

Table 5

Variables predictive of EFS in randomized non-CR patients

Variable	N	Events	HR (95% CI)	P*	P†
Binet Stage
B	72	33	1
C	22	13	1.3 (0.7; 2.5)	.4
Sex
Male	77	37	1
Female	17	9	1.2 (0.6; 2.6)	.6
Age, y			1.0 (0.99; 1.09)	.2
LDH
≤ N	51	22	1
> N	39	23	1.7 (0.9; 3.1)	.09
Beta2-m
Normal	17	10	1
Abnormal	61	30	0.8 (0.4; 1.7)	.6
CD38
≤ 22	50	19	1
> 22	44	27	1.7 (0.9; 3.1)	.08
Karyotype
Normal	28	11	1
At least one abnormality	49	27	1.4 (0.7; 2.9)	.3
Translocation
No	52	22	1
Yes (balanced and imbalanced)	25	16	1.8 (0.9; 3.6)	.07
Trisomy 12
No	79	39	1
Yes	7	4	1.2 (0.4; 3.4)	.7
Deletion (11q23)
No	59	29	1
Yes	25	14	1.2 (0.6; 2.4)	.5
Deletion (13q)					·
No	32	16	1
Yes	51	26	1.0 (0.5; 2.0)	.9
Deletion (17p13)
No	75	35	1
Yes	9	8	5.2 (2.2; 12.1)	.0001	.007
IgVH mutation
No	64	37	1
Yes	23	6	0.3 (0.1; 0.8)	.01	.03
ZAP70
Negative	15	5	1
Positive	38	29	2.4 (0.9; 6.5)	.09

Variable	N	Events	HR (95% CI)	P*	P†
Binet Stage
B	72	33	1
C	22	13	1.3 (0.7; 2.5)	.4
Sex
Male	77	37	1
Female	17	9	1.2 (0.6; 2.6)	.6
Age, y			1.0 (0.99; 1.09)	.2
LDH
≤ N	51	22	1
> N	39	23	1.7 (0.9; 3.1)	.09
Beta2-m
Normal	17	10	1
Abnormal	61	30	0.8 (0.4; 1.7)	.6
CD38
≤ 22	50	19	1
> 22	44	27	1.7 (0.9; 3.1)	.08
Karyotype
Normal	28	11	1
At least one abnormality	49	27	1.4 (0.7; 2.9)	.3
Translocation
No	52	22	1
Yes (balanced and imbalanced)	25	16	1.8 (0.9; 3.6)	.07
Trisomy 12
No	79	39	1
Yes	7	4	1.2 (0.4; 3.4)	.7
Deletion (11q23)
No	59	29	1
Yes	25	14	1.2 (0.6; 2.4)	.5
Deletion (13q)					·
No	32	16	1
Yes	51	26	1.0 (0.5; 2.0)	.9
Deletion (17p13)
No	75	35	1
Yes	9	8	5.2 (2.2; 12.1)	.0001	.007
IgVH mutation
No	64	37	1
Yes	23	6	0.3 (0.1; 0.8)	.01	.03
ZAP70
Negative	15	5	1
Positive	38	29	2.4 (0.9; 6.5)	.09

Models adjusted on the randomization arm and stratified for the Binet stage.

Multivariable models incorporating all covariates with P values reported, including the randomization arm, with stratification for Binet stage.