Published guidelines for reversal of warfarin anticoagulation in patients with intracerebral hemorrhage
| Society (year) . | Vitamin K (mg) . | Plasma (mL/kg) . | . | PCC (U/kg) . | rFVII . |
|---|---|---|---|---|---|
| Australian (2004)22 | IV (5-10) | Yes (NS) | AND | Yes (NS)* | NS |
| British Standards(2005) 13,16,18 | IV (5-10) | Yes (15) | OR | Preferred (50) | NS |
| EU Stroke (2006)20 | IV (5-10) | Yes (10-40) | OR | Yes (10-50) | NS |
| ACCP (2008)21 | IV (10) | Yes (NS) | OR | Preferred (NS) | Yes† |
| AHA (2010)23 | IV (NS) | Yes (10-15) | OR | Yes (NS) | No |
| French (2010)24 | Oral or IV (10) | Yes (NS)‡ | OR | Preferred (25-50) | No |
| Society (year) . | Vitamin K (mg) . | Plasma (mL/kg) . | . | PCC (U/kg) . | rFVII . |
|---|---|---|---|---|---|
| Australian (2004)22 | IV (5-10) | Yes (NS) | AND | Yes (NS)* | NS |
| British Standards(2005) 13,16,18 | IV (5-10) | Yes (15) | OR | Preferred (50) | NS |
| EU Stroke (2006)20 | IV (5-10) | Yes (10-40) | OR | Yes (10-50) | NS |
| ACCP (2008)21 | IV (10) | Yes (NS) | OR | Preferred (NS) | Yes† |
| AHA (2010)23 | IV (NS) | Yes (10-15) | OR | Yes (NS) | No |
| French (2010)24 | Oral or IV (10) | Yes (NS)‡ | OR | Preferred (25-50) | No |
PCC indicates prothrombin complex concentrate; rFVIIa, recombinant human activated factor VII; IV, intravenous; NS, not specified; EU, European Union; ACCP, American College of Chest Physicians; and AHA, American Heart Association.
If a 3-factor PCC is administered, fresh frozen plasma is also recommended as a source of factor VII.
Use of PCCs or rFVIIa may vary, depending on availability.
Use of plasma only when PCCs are not available.