Most significant microRNAs associated with cytogenetics and molecular features in AML
| Chromosome aberration . | microRNA . | |
|---|---|---|
| Up-regulated . | Down-regulated . | |
| t(15;17)21,36,37 | miR-127 | miR-17 |
| miR-299 | miR-126 | |
| miR-323 | ||
| miR-368 | ||
| miR-382 | ||
| t(8;21)21,23,36,37 | miR-126/miR-126* | miR-133 |
| inv(16) | ||
| t(11q23)/MLL21,22,36-38 | miR-326 | miR-29s |
| miR-219 | miR-34a | |
| miR-17-92 | miR-16 | |
| miR-196a | ||
| Trisomy 822 | miR-124a | |
| miR-30d | ||
| Cytogenetically normal | ||
| Gene alteration | ||
| NPM1 mutation21,39-41 | miR-10a/-10b | miR-204 |
| miR-196a | miR-128 | |
| miR-196b | miR-126 | |
| miR-130a | ||
| miR-451 | ||
| FLT3-ITD21-23,39 | miR-155 | |
| CEBPA mutation21,42,43 | miR-181a | miR-34a |
| miR-335 | ||
| BAALC overexpression44 | miR-148a | |
| MN1 overexpression45 | miR-126 | miR-16 |
| miR-126* | miR-17-92 | |
| miR-424 | miR-100 | |
| miR-196a | ||
| Chromosome aberration . | microRNA . | |
|---|---|---|
| Up-regulated . | Down-regulated . | |
| t(15;17)21,36,37 | miR-127 | miR-17 |
| miR-299 | miR-126 | |
| miR-323 | ||
| miR-368 | ||
| miR-382 | ||
| t(8;21)21,23,36,37 | miR-126/miR-126* | miR-133 |
| inv(16) | ||
| t(11q23)/MLL21,22,36-38 | miR-326 | miR-29s |
| miR-219 | miR-34a | |
| miR-17-92 | miR-16 | |
| miR-196a | ||
| Trisomy 822 | miR-124a | |
| miR-30d | ||
| Cytogenetically normal | ||
| Gene alteration | ||
| NPM1 mutation21,39-41 | miR-10a/-10b | miR-204 |
| miR-196a | miR-128 | |
| miR-196b | miR-126 | |
| miR-130a | ||
| miR-451 | ||
| FLT3-ITD21-23,39 | miR-155 | |
| CEBPA mutation21,42,43 | miR-181a | miR-34a |
| miR-335 | ||
| BAALC overexpression44 | miR-148a | |
| MN1 overexpression45 | miR-126 | miR-16 |
| miR-126* | miR-17-92 | |
| miR-424 | miR-100 | |
| miR-196a | ||