Response to second-generation TKIs (analyzed by intention to treat)
| Parameter . | % response . | P . | ||
|---|---|---|---|---|
| Overall (n = 123) . | Dasatinib (n = 78) . | Nilotinib (n = 45) . | ||
| CHR | 86 | 87 | 84 | .75 |
| Cytogenetic response | 74 | 76 | 71 | .67 |
| Major | 63 | 64 | 62 | .85 |
| Complete | 59 | 60 | 56 | .70 |
| Any CyR at 6 months | 60 | 63 | 55 | .44 |
| Any CyR at 12 months | 63 | 69 | 51 | .07 |
| CCyR at 6 months | 39 | 41 | 36 | .70 |
| CCyR at 12 months | 43 | 48 | 35 | .18 |
| Parameter . | % response . | P . | ||
|---|---|---|---|---|
| Overall (n = 123) . | Dasatinib (n = 78) . | Nilotinib (n = 45) . | ||
| CHR | 86 | 87 | 84 | .75 |
| Cytogenetic response | 74 | 76 | 71 | .67 |
| Major | 63 | 64 | 62 | .85 |
| Complete | 59 | 60 | 56 | .70 |
| Any CyR at 6 months | 60 | 63 | 55 | .44 |
| Any CyR at 12 months | 63 | 69 | 51 | .07 |
| CCyR at 6 months | 39 | 41 | 36 | .70 |
| CCyR at 12 months | 43 | 48 | 35 | .18 |
CyR indicates cytogenetic response; and CCyR, complete cytogenetic response.