Significant associations (P < 3.1 × 10 × 10−5) of PEAR1 and NTRK1 gene variants with platelet function phenotypes after aspirin treatment
| Chrom1 position . | SNP rs no. . | Gene . | Role . | MA(F) . | Col2 . | Col5 . | ADP2 . | ADP10 . | Epi2 . | Epi10 . |
|---|---|---|---|---|---|---|---|---|---|---|
| European ancestry | ||||||||||
| 155114730 | rs2644604 | NTRK1 | Intron | A (0.112) | .0011 | 3.59 × 10−5 | .0026 | .0334 | 2.17 × 10−5 | .0008 |
| 155122419 | rs12564129 | Intergenic | C (0.047) | .0015 | .0025 | .0505 | .2934 | 3.36 × 10−6 | 1.77 × 10−6 | |
| 155135671 | rs12566888 | PEAR1 | Intron | T (0.092) | 6.99 × 10−6 | 5.43 × 10−5 | .0002 | .0125 | 3.48 × 10−8 | 4.50 × 10−5 |
| 155136338 | rs12041331 | PEAR1 | Intron | A (0.091) | 8.76 × 10−7 | 4.57 × 10−7 | .0002 | .0060 | 2.22 × 10−8 | 7.55 × 10−7 |
| 155146204 | rs3737224 | PEAR1 | Coding-syn | T (0.117) | .0022 | .0041 | .1729 | .0099 | 2.69 × 10−7 | 7.93 × 10−5 |
| African ancestry* | ||||||||||
| 155114730 | rs2644604 | NTRK1 | Intron | A (0.284) | 4.76 × 10−5 | 1.60 × 10−6 | 3.33 × 10−6 | 3.48 × 10−6 | 3.01 × 10−10 | 7.95 × 10−9 |
| 155135671 | rs12566888 | PEAR1 | Intron | G (0.463) | 7.67 × 10−7 | 1.20 × 10−8 | 2.19 × 10−5 | 3.68 × 10−7 | 3.30 × 10−9 | 3.49 × 10−9 |
| 155136338 | rs12041331 | PEAR1 | Intron | A (0.371) | 1.15 × 10−9 | 7.83 × 10−14 | 8.53 × 10−13 | 4.73 × 10−14 | 2.31 × 10−27 | 1.58 × 10−25 |
| Chrom1 position . | SNP rs no. . | Gene . | Role . | MA(F) . | Col2 . | Col5 . | ADP2 . | ADP10 . | Epi2 . | Epi10 . |
|---|---|---|---|---|---|---|---|---|---|---|
| European ancestry | ||||||||||
| 155114730 | rs2644604 | NTRK1 | Intron | A (0.112) | .0011 | 3.59 × 10−5 | .0026 | .0334 | 2.17 × 10−5 | .0008 |
| 155122419 | rs12564129 | Intergenic | C (0.047) | .0015 | .0025 | .0505 | .2934 | 3.36 × 10−6 | 1.77 × 10−6 | |
| 155135671 | rs12566888 | PEAR1 | Intron | T (0.092) | 6.99 × 10−6 | 5.43 × 10−5 | .0002 | .0125 | 3.48 × 10−8 | 4.50 × 10−5 |
| 155136338 | rs12041331 | PEAR1 | Intron | A (0.091) | 8.76 × 10−7 | 4.57 × 10−7 | .0002 | .0060 | 2.22 × 10−8 | 7.55 × 10−7 |
| 155146204 | rs3737224 | PEAR1 | Coding-syn | T (0.117) | .0022 | .0041 | .1729 | .0099 | 2.69 × 10−7 | 7.93 × 10−5 |
| African ancestry* | ||||||||||
| 155114730 | rs2644604 | NTRK1 | Intron | A (0.284) | 4.76 × 10−5 | 1.60 × 10−6 | 3.33 × 10−6 | 3.48 × 10−6 | 3.01 × 10−10 | 7.95 × 10−9 |
| 155135671 | rs12566888 | PEAR1 | Intron | G (0.463) | 7.67 × 10−7 | 1.20 × 10−8 | 2.19 × 10−5 | 3.68 × 10−7 | 3.30 × 10−9 | 3.49 × 10−9 |
| 155136338 | rs12041331 | PEAR1 | Intron | A (0.371) | 1.15 × 10−9 | 7.83 × 10−14 | 8.53 × 10−13 | 4.73 × 10−14 | 2.31 × 10−27 | 1.58 × 10−25 |
P values are shown for each genotype-phenotype association signal.
MA(F) indicates minor allele (frequency); Col2 and 5, aggregation to collagen 2 and 5 μg/mL, respectively; ADP2 and 10, aggregation to ADP 2 and 10μM, respectively; and Epi2 and 10, aggregation to epinephrine 2 and 10μM, respectively.
Significant SNPs in common with participants of EA.