Hematologic parameters in wt, Hfe-KO, and Hamp-KO female mice
| . | Hb, g/dL . | RBC, ×106/μL . | Hct, % . | MCV, fL . | MCH, pg . | Retic, ×109/L . | LIC, μg/mg dry . | SI, μg/dL . | Tf Sat, % . |
|---|---|---|---|---|---|---|---|---|---|
| wt (2 months) | 15.5 ± 0.3 | 9.8 ± 0.5 | 47.0 ± 0.7 | 45.9 ± 0.3 | 15.2 ± 0.1 | 285 ± 14 | 0.29 ± 0.04 | 121 ± 39 | 53 ± 11 |
| wt (5 months) | 15.4 ± 0.2 | 10.0 ± 0.1 | 44.4 ± 0.5 | 44.3 ± 0.4 | 15.3 ± 0.1 | 246 ± 15 | 0.41 ± 0.09 | 123 ± 15 | 58 ± 14 |
| wt (12 months) | 15.2 ± 0.2 | 11.0 ± 0.1 | 49.7 ± 0.9 | 45.2 ± 0.6 | 13.9 ± 0.2 | 377 ± 28 | 0.43 ± 0.09 | 153 ± 25 | 53 ± 14 |
| Hfe-KO (2 months) | 16.6 ± 0.2† | 10.2 ± 0.1 | 48.8 ± 0.7 | 48.2 ± 0.3† | 16.4 ± 0.1‡ | 310 ± 10 | 1.36 ± 0.32‡ | 219 ± 20* | 89 ± 14* |
| Hfe-KO (5 months) | 16.2 ± 0.3* | 9.8 ± 0.2 | 46.9 ± 0.6† | 47.9 ± 0.5† | 16.5 ± 0.2‡ | 260 ± 17 | 1.59 ± 0.25‡ | 233 ± 20† | 91 ± 14† |
| Hfe-KO (12 months) | 15.7 ± 0.3 | 9.9 ± 0.2† | 47.3 ± 0.7* | 48.2 ± 0.7† | 16.0 ± 0.3‡ | 260 ± 35* | 1.87 ± 0.25‡ | 310 ± 10† | 86 ± 14‡ |
| Hamp-KO (2 months) | 15.7 ± 0.1§ | 9.9 ± 0.1 | 46.7 ± 0.5 | 47.0 ± 0.2*§ | 15.7 ± 0.2*§ | 305 ± 75 | 3.64 ± 0.48†§ | NA | NA |
| . | Hb, g/dL . | RBC, ×106/μL . | Hct, % . | MCV, fL . | MCH, pg . | Retic, ×109/L . | LIC, μg/mg dry . | SI, μg/dL . | Tf Sat, % . |
|---|---|---|---|---|---|---|---|---|---|
| wt (2 months) | 15.5 ± 0.3 | 9.8 ± 0.5 | 47.0 ± 0.7 | 45.9 ± 0.3 | 15.2 ± 0.1 | 285 ± 14 | 0.29 ± 0.04 | 121 ± 39 | 53 ± 11 |
| wt (5 months) | 15.4 ± 0.2 | 10.0 ± 0.1 | 44.4 ± 0.5 | 44.3 ± 0.4 | 15.3 ± 0.1 | 246 ± 15 | 0.41 ± 0.09 | 123 ± 15 | 58 ± 14 |
| wt (12 months) | 15.2 ± 0.2 | 11.0 ± 0.1 | 49.7 ± 0.9 | 45.2 ± 0.6 | 13.9 ± 0.2 | 377 ± 28 | 0.43 ± 0.09 | 153 ± 25 | 53 ± 14 |
| Hfe-KO (2 months) | 16.6 ± 0.2† | 10.2 ± 0.1 | 48.8 ± 0.7 | 48.2 ± 0.3† | 16.4 ± 0.1‡ | 310 ± 10 | 1.36 ± 0.32‡ | 219 ± 20* | 89 ± 14* |
| Hfe-KO (5 months) | 16.2 ± 0.3* | 9.8 ± 0.2 | 46.9 ± 0.6† | 47.9 ± 0.5† | 16.5 ± 0.2‡ | 260 ± 17 | 1.59 ± 0.25‡ | 233 ± 20† | 91 ± 14† |
| Hfe-KO (12 months) | 15.7 ± 0.3 | 9.9 ± 0.2† | 47.3 ± 0.7* | 48.2 ± 0.7† | 16.0 ± 0.3‡ | 260 ± 35* | 1.87 ± 0.25‡ | 310 ± 10† | 86 ± 14‡ |
| Hamp-KO (2 months) | 15.7 ± 0.1§ | 9.9 ± 0.1 | 46.7 ± 0.5 | 47.0 ± 0.2*§ | 15.7 ± 0.2*§ | 305 ± 75 | 3.64 ± 0.48†§ | NA | NA |
Values are mean ± SEM of 5 to 20 female mice.
Hct indicates hematocrit; MCV, mean corpuscular volume; Retic, reticulocyte count; LIC, liver iron concentration; SI, serum iron; Tf Sat, transferrin saturation; and NA, not applicable.
P ≤ .05 relative to age-matched wt controls.
P ≤ .01 relative to age-matched wt controls.
P ≤ .001 relative to age-matched wt controls.
P ≤ .05 relative to 2-month-old Hfe-KO mice.