Key features of different strategies for ATCI of leukemia
| Key features . | Ag receptor . | ||||
|---|---|---|---|---|---|
| Endogenous TCR . | Transfected TCR . | CARs . | |||
| MiHAs* . | LAAs* . | MiHAs* . | LAAs* . | Cell-surface molecules* . | |
| MHC restricted | + | + | + | + | − |
| Dependent on the recipient's MiHA genotype | + | − | + | − | − |
| Dependent on LAA expression by leukemic cells | − | + | − | + | − |
| Requires massive in vitro expansion of Ag-specific T cells | + | + | − | − | − |
| Ag receptor is monoclonal | − | − | + | + | + |
| Limited to cell-surface molecules (generally not leukemia specific) | − | − | − | − | + |
| Target Ag can originate from all cell compartments | + | + | + | + | − |
| T cells can be allogeneic or autologous | −† | + | + | + | + |
| Key features . | Ag receptor . | ||||
|---|---|---|---|---|---|
| Endogenous TCR . | Transfected TCR . | CARs . | |||
| MiHAs* . | LAAs* . | MiHAs* . | LAAs* . | Cell-surface molecules* . | |
| MHC restricted | + | + | + | + | − |
| Dependent on the recipient's MiHA genotype | + | − | + | − | − |
| Dependent on LAA expression by leukemic cells | − | + | − | + | − |
| Requires massive in vitro expansion of Ag-specific T cells | + | + | − | − | − |
| Ag receptor is monoclonal | − | − | + | + | + |
| Limited to cell-surface molecules (generally not leukemia specific) | − | − | − | − | + |
| Target Ag can originate from all cell compartments | + | + | + | + | − |
| T cells can be allogeneic or autologous | −† | + | + | + | + |