Table 2

Pharmacogenetics-based loading dose grid according to VKORC1 and CYP2C9 genotype

VKORC1CYP2C9
*1/*1*1/*2 or *1/*3*2/*2, *2/*3, *3/*3
G/G 10 10 7.5 
G/A 10 7.5 5 
A/A 5 5 5 
VKORC1CYP2C9
*1/*1*1/*2 or *1/*3*2/*2, *2/*3, *3/*3
G/G 10 10 7.5 
G/A 10 7.5 5 
A/A 5 5 5 

Loading doses are in milligrams.

Loading dose was adjusted to 7.5 mg for patients with weight < 60 kg.

Loading dose was decreased by 2.5 mg for patients with weight < 45 kg.

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