Table 2

(KD) of pAT and AT variants with fondaparinux binding

AntithrombinKD ± SEM, nM
pAT 22.0 ± 3.3 
AT-N135Q 8.6 ± 1.4 
AT-N135Q-Pro394 8.3 ± 1.3 
AntithrombinKD ± SEM, nM
pAT 22.0 ± 3.3 
AT-N135Q 8.6 ± 1.4 
AT-N135Q-Pro394 8.3 ± 1.3 

KD were estimated by intrinsic fluorescence enhancement of AT (100nM) upon fondaparinux (0-400nM) binding, assuming a stoechiometry of 1:1.

AT indicates antithrombin; KD, dissociation constants; and pAT, plasma AT.

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