Table 1 Diagnostic features of FLIS and... | American Society of Hematology

Table 1

Diagnostic features of FLIS and PFL

FLIS	PFL
Architecture intact	Altered architecture
Follicle size normal	Follicle size often expanded
Involved follicles widely scattered	Involved follicles grouped together in LN
Intact cuff with sharp edge to GC	Blurred edge to GC and attenuated cuff
Very strong expression of BCL2 and CD10	BCL2 and CD10 more variable in intensity
Almost pure centrocytes	Centrocytes with few centroblasts
Atypical cells confined to GC	Atypical cells (CD10⁺/BCL2⁺ B cells) may be found outside the GC

FLIS	PFL
Architecture intact	Altered architecture
Follicle size normal	Follicle size often expanded
Involved follicles widely scattered	Involved follicles grouped together in LN
Intact cuff with sharp edge to GC	Blurred edge to GC and attenuated cuff
Very strong expression of BCL2 and CD10	BCL2 and CD10 more variable in intensity
Almost pure centrocytes	Centrocytes with few centroblasts
Atypical cells confined to GC	Atypical cells (CD10⁺/BCL2⁺ B cells) may be found outside the GC

GC indicates germinal center.