Histologic scoring, clinical features, and follow-up of FLIS cases
Case no. . | Age, y/sex . | Site/FLIS . | Degree of involvement by FLIS* . | Site of recurrence . | Time to FL, months† . |
---|---|---|---|---|---|
20 cases with no other evidence of lymphoma | |||||
18 | 63/F | Thyroid, thyroiditis | 1A | — | NEL (102) |
2‡ | 37/M | LN, L inguinal | 1A | — | NEL (111) |
3‡ | 41/F | LN, L axillary | 1A | — | NEL (73) |
4 | 61/M | LN, R submandibular | 1A | — | NEL (79) |
5 | 73/F | LN, L inguinal | 1A | — | NEL (33) |
6 | 50/F | LN, R inguinal | 1A | — | NEL (16) |
7‡ | 53/F | LN, R axillary | 2A | — | NEL (74) |
8‡ | 23/F | LN, L inguinal | 2B | — | NEL (96) |
9‡ | 52/F | LN, L axillary | 2B | — | NEL (19) |
10 | 48/F | LN, L parotid | 2B | — | NEL (41) |
11 | 59/M | LN, pretracheal | 2B | — | NEL (3)§ |
12 | 53/F | LN, R cervical | 3A | — | NEL (48) |
13 | 51/M | LN, R chest | 3B | — | NEL (118) |
14‡ | 52/F | LN, R cervical | 3B | — | NEL (84) |
15 | 48/F | LN, supraclavicular | 3B | — | NEL (30) |
16 | 69/M | LN, mesenteric | 3B | — | NEL (12) |
17 | 74/F | LN, mesenteric | 3B | — | NEL (15) |
18 | 23/F | LN, mesenteric | 3B | — | NEL (12) |
19 | 42/F | LN, R axillary | 3B | — | NEL (10) |
20 | 31/M | Jejunum LN, mesenteric | 1B (jejunum) 3B (LN) | — | NEL (57) |
1 case with subsequent development of FL | |||||
21‡ | 76/M | LN, R inguinal | 1A | FL, low-grade/LN, R inguinal | 29 |
3 cases with prior or coexisting FL (BCL2+) | |||||
22‡ | 42/M | LN, R cervical | 1A | FL, low-grade/LN, R cervical | 0 |
23 | 45/M | LN, NOS | 1A | Prior FL, site unknown | 0 |
24 | 49/F | LN, retroperitoneal | 3A | Prior FL, low-grade/LN, L axillary | 0 |
2 cases with no available follow-up | |||||
25 | 60/M | LN, submental | 1A | — | NA |
26 | 42/M | LN, R thigh | 2A | — | NA |
3 cases with BCL2-negative FL | |||||
27 | 74/F | LN, L parotid | 1A | — | 0 |
28 | 51/M | LN, L parotid | 1A | — | 0 |
29 | 57/F | LN, L cervical | 1A | — | 0‖ |
5 cases with miscellaneous composite lymphoma | |||||
30 | 70/F | LN, L scalene | 1A | CLL/SLL κ¶ | DLBCL (48)¶ |
31‡ | 53/M | LN, bilateral pelvic | 2A | CLL/SLL | NEFL (108)# |
32 | 41/M | LN, L axillary | 3B | Interfollicular cHL | NEFL (21)** |
33 | 48/F | LN, L cervical, R axillary | 3B | Nodal marginal zone lymphoma | NEL (18)†† |
34‡ | 63/M | LN, scalene | 2B | LPL | NEFL (40) |
Case no. . | Age, y/sex . | Site/FLIS . | Degree of involvement by FLIS* . | Site of recurrence . | Time to FL, months† . |
---|---|---|---|---|---|
20 cases with no other evidence of lymphoma | |||||
18 | 63/F | Thyroid, thyroiditis | 1A | — | NEL (102) |
2‡ | 37/M | LN, L inguinal | 1A | — | NEL (111) |
3‡ | 41/F | LN, L axillary | 1A | — | NEL (73) |
4 | 61/M | LN, R submandibular | 1A | — | NEL (79) |
5 | 73/F | LN, L inguinal | 1A | — | NEL (33) |
6 | 50/F | LN, R inguinal | 1A | — | NEL (16) |
7‡ | 53/F | LN, R axillary | 2A | — | NEL (74) |
8‡ | 23/F | LN, L inguinal | 2B | — | NEL (96) |
9‡ | 52/F | LN, L axillary | 2B | — | NEL (19) |
10 | 48/F | LN, L parotid | 2B | — | NEL (41) |
11 | 59/M | LN, pretracheal | 2B | — | NEL (3)§ |
12 | 53/F | LN, R cervical | 3A | — | NEL (48) |
13 | 51/M | LN, R chest | 3B | — | NEL (118) |
14‡ | 52/F | LN, R cervical | 3B | — | NEL (84) |
15 | 48/F | LN, supraclavicular | 3B | — | NEL (30) |
16 | 69/M | LN, mesenteric | 3B | — | NEL (12) |
17 | 74/F | LN, mesenteric | 3B | — | NEL (15) |
18 | 23/F | LN, mesenteric | 3B | — | NEL (12) |
19 | 42/F | LN, R axillary | 3B | — | NEL (10) |
20 | 31/M | Jejunum LN, mesenteric | 1B (jejunum) 3B (LN) | — | NEL (57) |
1 case with subsequent development of FL | |||||
21‡ | 76/M | LN, R inguinal | 1A | FL, low-grade/LN, R inguinal | 29 |
3 cases with prior or coexisting FL (BCL2+) | |||||
22‡ | 42/M | LN, R cervical | 1A | FL, low-grade/LN, R cervical | 0 |
23 | 45/M | LN, NOS | 1A | Prior FL, site unknown | 0 |
24 | 49/F | LN, retroperitoneal | 3A | Prior FL, low-grade/LN, L axillary | 0 |
2 cases with no available follow-up | |||||
25 | 60/M | LN, submental | 1A | — | NA |
26 | 42/M | LN, R thigh | 2A | — | NA |
3 cases with BCL2-negative FL | |||||
27 | 74/F | LN, L parotid | 1A | — | 0 |
28 | 51/M | LN, L parotid | 1A | — | 0 |
29 | 57/F | LN, L cervical | 1A | — | 0‖ |
5 cases with miscellaneous composite lymphoma | |||||
30 | 70/F | LN, L scalene | 1A | CLL/SLL κ¶ | DLBCL (48)¶ |
31‡ | 53/M | LN, bilateral pelvic | 2A | CLL/SLL | NEFL (108)# |
32 | 41/M | LN, L axillary | 3B | Interfollicular cHL | NEFL (21)** |
33 | 48/F | LN, L cervical, R axillary | 3B | Nodal marginal zone lymphoma | NEL (18)†† |
34‡ | 63/M | LN, scalene | 2B | LPL | NEFL (40) |
— indicates not applicable; NOS, not otherwise specified; DLBCL, diffuse large B-cell lymphoma; NEFL, no evidence of follicular lymphoma; cHL, classic Hodgkin lymphoma; and NEL, no evidence of lymphoma.
Described in “Histology and immunochemistry” and Table 2.
Unless otherwise indicated, all patients were treated with excision and observation only.
Case included in original series.24
Patient died of germ cell tumor.
Patient treated with radiation, with no evidence of disease 88 months later.
The CLL/SLL was κ-positive; the patient developed DLBCL 48 months after diagnosis, which was λ-positive.
Patient treated with rituximab with Cytoxan, hydroxyrubicin, Oncovin, and prednisone (R-CHOP) chemotherapy.
Patient treated with adriamycin, bleomycin, vinblastine, and doxorubicin (ABVD) and radiation therapy.
Patient treated with rituximab.