Adverse events possibly, probably, and definitely attributed to imatinib
| Imatinib 200 mg daily . | Imatinib 400 mg daily . | ||||||
|---|---|---|---|---|---|---|---|
| Grade 1 . | Grade 2 or 3* . | Grade 1 . | Grades 2-5** . | ||||
| Adverse event . | Prevalence . | Adverse event . | Prevalence . | Adverse event . | Prevalence . | Adverse event . | Prevalence . |
| Nausea | 8/15 | LFT elevation | 2/15 | Muscle cramping | 3/12 | Diarrhea | 2/12 |
| Edema | 6/15 | Diarrhea | 1/15 | Diarrhea | 2/12 | Fatigue | 2/12 |
| Confusion | 4/15 | Edema | 1/15 | Edema | 2/12 | Muscle cramping | 2/12 |
| Diarrhea | 4/15 | Fatigue | 1/15 | Fatigue | 2/12 | Hypertension | 1/12 |
| LFT elevation | 4/15 | Thrombosis/vessel injury | 1/15 | Nausea | 2/12 | LFT | 1/12 |
| Fatigue | 3/15 | *No grade 4 or 5 toxicities observed at 200 mg daily | Anemia | 1/12 | Pulmonary infiltrates | 1/12 | |
| Myalgia | 3/15 | Fever | 1/12 | Cryptogenic organizing pneumonia | 1/12 | ||
| Flatulence | 2/15 | Flatulence | 1/12 | Tachycardia | 1/12 | ||
| Erythema | 1/15 | Joint soreness | 1/12 | H1N1 | 1/12 | ||
| Headache | 1/15 | LFT | 1/12 | Nausea | 1/12 | ||
| Heartburn | 1/15 | Thrombocytopenia | 1/12 | Slow wound healing | 1/12 | ||
| Neutropenia | 1/15 | Vomiting | 1/12 | **No grade 4 toxicities observed at 400 mg daily | |||
| Thrombocytopenia | 1/15 | Weight loss | 1/12 | ||||
| Weight loss | 1/15 | ||||||
| Imatinib 200 mg daily . | Imatinib 400 mg daily . | ||||||
|---|---|---|---|---|---|---|---|
| Grade 1 . | Grade 2 or 3* . | Grade 1 . | Grades 2-5** . | ||||
| Adverse event . | Prevalence . | Adverse event . | Prevalence . | Adverse event . | Prevalence . | Adverse event . | Prevalence . |
| Nausea | 8/15 | LFT elevation | 2/15 | Muscle cramping | 3/12 | Diarrhea | 2/12 |
| Edema | 6/15 | Diarrhea | 1/15 | Diarrhea | 2/12 | Fatigue | 2/12 |
| Confusion | 4/15 | Edema | 1/15 | Edema | 2/12 | Muscle cramping | 2/12 |
| Diarrhea | 4/15 | Fatigue | 1/15 | Fatigue | 2/12 | Hypertension | 1/12 |
| LFT elevation | 4/15 | Thrombosis/vessel injury | 1/15 | Nausea | 2/12 | LFT | 1/12 |
| Fatigue | 3/15 | *No grade 4 or 5 toxicities observed at 200 mg daily | Anemia | 1/12 | Pulmonary infiltrates | 1/12 | |
| Myalgia | 3/15 | Fever | 1/12 | Cryptogenic organizing pneumonia | 1/12 | ||
| Flatulence | 2/15 | Flatulence | 1/12 | Tachycardia | 1/12 | ||
| Erythema | 1/15 | Joint soreness | 1/12 | H1N1 | 1/12 | ||
| Headache | 1/15 | LFT | 1/12 | Nausea | 1/12 | ||
| Heartburn | 1/15 | Thrombocytopenia | 1/12 | Slow wound healing | 1/12 | ||
| Neutropenia | 1/15 | Vomiting | 1/12 | **No grade 4 toxicities observed at 400 mg daily | |||
| Thrombocytopenia | 1/15 | Weight loss | 1/12 | ||||
| Weight loss | 1/15 | ||||||