Table 3 Organ system responses to... | American Society of Hematology

Table 3

Organ system responses to imatinib

Patient no.	Time point	Cutaneous			Oral		Response
Patient no.	Time point	Lichenoid	Scleroderma	Fascial	Examination	Symptoms	Response
1	Pre	0	0	0	2	0	Baseline
	24 weeks	0	0	0	2	0	Stable
	Last	0	0	0	2	0	Stable
2	Pre	1	1	2	0	0	Baseline
	24 weeks	1	0	2	0	0	Minor*
	Last	1	0	2	0	0	Minor*
3	Pre	2	1	1	2	1	Baseline
	24 weeks	PD	PD	PD	PD	PD	Progression
	Last	PD	PD	PD	PD	PD	Progression
4	Pre	0	0	0	2	1	Baseline
	24 weeks	0	0	0	1	0	Minor*
	Last	0	0	0	1	0	Minor*
6	Pre	0	3	1	0	0	Baseline
	24 weeks	0	3	1	0	0	Stable
	Last	0	1	1	0	0	Major*
7	Pre	0	0	1	2	1	Baseline
	24 weeks	0	0	0	2	1	Minor*
	Last	0	0	0	1	0	Minor*
8	Pre	1	1	2	3	0	Baseline
	24 weeks	0	3†	2	3	0	Stable
	Last	0	1	1	1	0	Major*
10	Pre	1	0	0	2	0	Baseline
	24 weeks	1	0	0	2	0	Stable
	Last	1	0	0	2	0	Stable
11	Pre	1	3	0	2	1	Baseline
	24 weeks	1	1	0	2	1	Major*
	Last	PD	PD	PD	PD	PD	Progression
12	Pre	2	3	2	2	1	Baseline
	24 weeks	2	3	1	2	1	Minor*
	Last	1	3	1	0	0	Major*
15	Pre	1	2	2	2	0	Baseline
	24 weeks	0	3	2	1	0	Stable
	Last	0	3	2	2	0	Stable

Patient no.	Time point	Cutaneous			Oral		Response
Patient no.	Time point	Lichenoid	Scleroderma	Fascial	Examination	Symptoms	Response
1	Pre	0	0	0	2	0	Baseline
	24 weeks	0	0	0	2	0	Stable
	Last	0	0	0	2	0	Stable
2	Pre	1	1	2	0	0	Baseline
	24 weeks	1	0	2	0	0	Minor*
	Last	1	0	2	0	0	Minor*
3	Pre	2	1	1	2	1	Baseline
	24 weeks	PD	PD	PD	PD	PD	Progression
	Last	PD	PD	PD	PD	PD	Progression
4	Pre	0	0	0	2	1	Baseline
	24 weeks	0	0	0	1	0	Minor*
	Last	0	0	0	1	0	Minor*
6	Pre	0	3	1	0	0	Baseline
	24 weeks	0	3	1	0	0	Stable
	Last	0	1	1	0	0	Major*
7	Pre	0	0	1	2	1	Baseline
	24 weeks	0	0	0	2	1	Minor*
	Last	0	0	0	1	0	Minor*
8	Pre	1	1	2	3	0	Baseline
	24 weeks	0	3†	2	3	0	Stable
	Last	0	1	1	1	0	Major*
10	Pre	1	0	0	2	0	Baseline
	24 weeks	1	0	0	2	0	Stable
	Last	1	0	0	2	0	Stable
11	Pre	1	3	0	2	1	Baseline
	24 weeks	1	1	0	2	1	Major*
	Last	PD	PD	PD	PD	PD	Progression
12	Pre	2	3	2	2	1	Baseline
	24 weeks	2	3	1	2	1	Minor*
	Last	1	3	1	0	0	Major*
15	Pre	1	2	2	2	0	Baseline
	24 weeks	0	3	2	1	0	Stable
	Last	0	3	2	2	0	Stable

Patients 5, 9, 13, and 14 were not evaluable for organ system response.

Participants with overall responses.

Flare in cGVHD symptoms (secondary to upper respiratory infection) managed with transient increase in corticosteroids.