Table 5 Pharmacodynamic effect of... | American Society of Hematology

Table 5

Pharmacodynamic effect of imatinib on PDGFRA and PDGFRB phosphorylation

Patient no.	Clinical response	Sample	Phospho-PDGFRA/PDGFRA	Phospho-PDGFRB/PDGFRB
1	Stable disease with steroid reduction	Pre	.67	.33
1	Stable disease with steroid reduction	Post	.33	.4
6	Major response	Pre	.33	.2
6	Major response	Post	.33	0
11	Progressive disease	Pre	.67	.8
11	Progressive disease	Post	.67	.4
12	Major response	Pre	.33	.33
12	Major response	Post	.33	.33

Patient no.	Clinical response	Sample	Phospho-PDGFRA/PDGFRA	Phospho-PDGFRB/PDGFRB
1	Stable disease with steroid reduction	Pre	.67	.33
1	Stable disease with steroid reduction	Post	.33	.4
6	Major response	Pre	.33	.2
6	Major response	Post	.33	0
11	Progressive disease	Pre	.67	.8
11	Progressive disease	Post	.67	.4
12	Major response	Pre	.33	.33
12	Major response	Post	.33	.33