Multivariate analysis of risk factors for NRM and survival in 1117 pediatric patients with cGVHD
| . | NRM . | Survival . | ||||
|---|---|---|---|---|---|---|
| Relative risk . | 95% CI . | P . | Relative risk . | 95% CI . | P . | |
| Age (baseline: 0-9 y) | ||||||
| 10-19 y | NS | — | — | 1.32 | 1.09; 1.60 | .005 |
| KPS/L (baseline: 80-100) | — | — | < .001 | — | — | < .001 |
| < 80 | 3.01 | 2.29; 3.96 | < .001 | 1.89 | 1.52; 2.34 | < .001 |
| Unknown | 1.64 | 1.12; 2.43 | .015 | 1.34 | 1.00; 1.78 | .05 |
| Platelets, × 109/L (baseline: ≥ 100) | — | — | < .001 | — | — | < .001 |
| < 100 | 2.32 | 1.76; 3.07 | < .001 | 1.63 | 1.32; 2.01 | < .001 |
| Unknown | 1.73 | 1.18; 2.52 | .005 | 1.33 | 0.99; 1.78 | .06 |
| Donor (baseline: HLA-identical siblings) | — | — | < .001 | — | — | .003 |
| Other related | 1.67 | 0.96; 2.96 | .07 | 1.68 | 1.13; 2.52 | .011 |
| HLA well-matched URD | 1.25 | 0.80; 1.96 | .33 | 1.40 | 1.02; 1.94 | .04 |
| Partially matched URD | 1.94 | 1.28; 2.94 | .002 | 1.69 | 1.23; 2.31 | .001 |
| Mismatched URD | 2.31 | 1.49; 3.59 | < .001 | 1.75 | 1.27; 2.42 | < .001 |
| No data | 1.22 | 0.60; 2.13 | .71 | 1.02 | 0.64; 1.62 | .94 |
| Disease state (baseline: early) | — | — | .005 | — | — | < .001 |
| Intermediate | 0.65 | 0.50; 0.85 | .07 | 0.96 | 0.78; 1.18 | .70 |
| Advanced | 0.92 | 0.63; 1.35 | .68 | 1.56 | 1.19; 2.04 | .001 |
| Graft (baseline: BM) | — | — | .002 | — | — | — |
| PB | 1.76 | 1.28; 2.41 | < .001 | NS | — | — |
| Cord blood | 1.07 | 0.67; 1.70 | .78 | NS | — | — |
| . | NRM . | Survival . | ||||
|---|---|---|---|---|---|---|
| Relative risk . | 95% CI . | P . | Relative risk . | 95% CI . | P . | |
| Age (baseline: 0-9 y) | ||||||
| 10-19 y | NS | — | — | 1.32 | 1.09; 1.60 | .005 |
| KPS/L (baseline: 80-100) | — | — | < .001 | — | — | < .001 |
| < 80 | 3.01 | 2.29; 3.96 | < .001 | 1.89 | 1.52; 2.34 | < .001 |
| Unknown | 1.64 | 1.12; 2.43 | .015 | 1.34 | 1.00; 1.78 | .05 |
| Platelets, × 109/L (baseline: ≥ 100) | — | — | < .001 | — | — | < .001 |
| < 100 | 2.32 | 1.76; 3.07 | < .001 | 1.63 | 1.32; 2.01 | < .001 |
| Unknown | 1.73 | 1.18; 2.52 | .005 | 1.33 | 0.99; 1.78 | .06 |
| Donor (baseline: HLA-identical siblings) | — | — | < .001 | — | — | .003 |
| Other related | 1.67 | 0.96; 2.96 | .07 | 1.68 | 1.13; 2.52 | .011 |
| HLA well-matched URD | 1.25 | 0.80; 1.96 | .33 | 1.40 | 1.02; 1.94 | .04 |
| Partially matched URD | 1.94 | 1.28; 2.94 | .002 | 1.69 | 1.23; 2.31 | .001 |
| Mismatched URD | 2.31 | 1.49; 3.59 | < .001 | 1.75 | 1.27; 2.42 | < .001 |
| No data | 1.22 | 0.60; 2.13 | .71 | 1.02 | 0.64; 1.62 | .94 |
| Disease state (baseline: early) | — | — | .005 | — | — | < .001 |
| Intermediate | 0.65 | 0.50; 0.85 | .07 | 0.96 | 0.78; 1.18 | .70 |
| Advanced | 0.92 | 0.63; 1.35 | .68 | 1.56 | 1.19; 2.04 | .001 |
| Graft (baseline: BM) | — | — | .002 | — | — | — |
| PB | 1.76 | 1.28; 2.41 | < .001 | NS | — | — |
| Cord blood | 1.07 | 0.67; 1.70 | .78 | NS | — | — |
NS indicates not significant; and —, not applicable.