Time of bleeding stops and starts (in minutes)
| . | Stop . | Start . | Stop . | Start . | Stop . | Start . | Stop . | Start . | Stop . | Start . | Stop . | Start . | Stop . | Start . | Stop . | Start . | Stop . | Start . | Stop . | Start . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WT 1 | 3:30 | 4:50 | 7:40 | 9:36 | 10:23 | |||||||||||||||
| WT 2 | 3:09 | 3:20 | 4:15 | 5:40 | 6:11 | 8:20 | 9:11 | 11:10 | 12:10 | 13:20 | 14:15 | 15:01 | 21:00 | 22:30 | ||||||
| WT 3 | 3:38 | 4:55 | 7:11 | 7:40 | 8:35 | 8:50 | 11:47 | 12:25 | ||||||||||||
| WT 4 | 3:30 | 5:54 | 6:28 | 7:20 | 8:05 | 9:00 | 9:41 | 11:36 | 12:03 | 13:50 | 14:39 | 15:50 | 17:04 | 18:12 | 18:40 | 18:56 | 23:23 | 26:12 | 27:33 | 29:13 |
| WT 5 | 4:17 | 6:14 | 7:40 | 8:54 | 11:01 | 12:06 | 15:45 | 17:20 | 19:50 | 21:33 | ||||||||||
| WT 6 | 2:57 | 6:29 | 11:03 | 13:16 | 17:37 | 20:04 | 21:50 | |||||||||||||
| −/− 1 | 0:45 | |||||||||||||||||||
| −/−2 | 0:50 | 2:30 | 4:00 | |||||||||||||||||
| −/−3 | 0:51 | 4:30 | 5:00 | |||||||||||||||||
| −/−4 | 0:58 | 10:40 | 11:02 | |||||||||||||||||
| −/−5 | 1:15 | 6:08 | 7:07 | 11:30 | 11:58 | 17:00 | 17:17 | |||||||||||||
| −/−6 | 1:01 | 5:31 | 5:55 |
| . | Stop . | Start . | Stop . | Start . | Stop . | Start . | Stop . | Start . | Stop . | Start . | Stop . | Start . | Stop . | Start . | Stop . | Start . | Stop . | Start . | Stop . | Start . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WT 1 | 3:30 | 4:50 | 7:40 | 9:36 | 10:23 | |||||||||||||||
| WT 2 | 3:09 | 3:20 | 4:15 | 5:40 | 6:11 | 8:20 | 9:11 | 11:10 | 12:10 | 13:20 | 14:15 | 15:01 | 21:00 | 22:30 | ||||||
| WT 3 | 3:38 | 4:55 | 7:11 | 7:40 | 8:35 | 8:50 | 11:47 | 12:25 | ||||||||||||
| WT 4 | 3:30 | 5:54 | 6:28 | 7:20 | 8:05 | 9:00 | 9:41 | 11:36 | 12:03 | 13:50 | 14:39 | 15:50 | 17:04 | 18:12 | 18:40 | 18:56 | 23:23 | 26:12 | 27:33 | 29:13 |
| WT 5 | 4:17 | 6:14 | 7:40 | 8:54 | 11:01 | 12:06 | 15:45 | 17:20 | 19:50 | 21:33 | ||||||||||
| WT 6 | 2:57 | 6:29 | 11:03 | 13:16 | 17:37 | 20:04 | 21:50 | |||||||||||||
| −/− 1 | 0:45 | |||||||||||||||||||
| −/−2 | 0:50 | 2:30 | 4:00 | |||||||||||||||||
| −/−3 | 0:51 | 4:30 | 5:00 | |||||||||||||||||
| −/−4 | 0:58 | 10:40 | 11:02 | |||||||||||||||||
| −/−5 | 1:15 | 6:08 | 7:07 | 11:30 | 11:58 | 17:00 | 17:17 | |||||||||||||
| −/−6 | 1:01 | 5:31 | 5:55 |
The last 3 mm of the mouse tail was clipped, and the tail was placed in 37°C saline. Time until cessation and reinitiation of bleeding was recorded. Bleeding-rebleeding was followed for 30 minutes.
WT indicates wild-type.