Median time to treatment and OS relative to specific SET protein isoform expression
| . | Time to treatment, y . | OS, y . | ||||
|---|---|---|---|---|---|---|
| High expression . | Low expression . | P* . | High expression . | Low expression . | P* . | |
| SETβ-isoform | 4.3 (3.7-6.2) | 6.4 (4.5-9.3) | .101 | 13.1 (11.3-NE) | 16.9 (13.7-28.2) | .229 |
| SETα-isoform | 3.8 (3.0-5.2) | 8.3 (5.8-16.3) | .0002 | 13.3 (11.3-22.6) | 20.6 (14.5-NE) | .247 |
| Total SET (α + β) | 4.3 (3.7-6.2) | 11.9 (5.8-NE) | .004 | 18.0 (12.3-28.3) | 16.7 (12.7-NE) | .997 |
| α/β ratio | 3.8 (3.1-5.2) | 11.9 (6.3-NE) | .0002 | 16.7 (10.6-22.6) | 20.8 (15.8-NE) | .008 |
| . | Time to treatment, y . | OS, y . | ||||
|---|---|---|---|---|---|---|
| High expression . | Low expression . | P* . | High expression . | Low expression . | P* . | |
| SETβ-isoform | 4.3 (3.7-6.2) | 6.4 (4.5-9.3) | .101 | 13.1 (11.3-NE) | 16.9 (13.7-28.2) | .229 |
| SETα-isoform | 3.8 (3.0-5.2) | 8.3 (5.8-16.3) | .0002 | 13.3 (11.3-22.6) | 20.6 (14.5-NE) | .247 |
| Total SET (α + β) | 4.3 (3.7-6.2) | 11.9 (5.8-NE) | .004 | 18.0 (12.3-28.3) | 16.7 (12.7-NE) | .997 |
| α/β ratio | 3.8 (3.1-5.2) | 11.9 (6.3-NE) | .0002 | 16.7 (10.6-22.6) | 20.8 (15.8-NE) | .008 |
Values are median (5th to 95th percentile).
NE indicates not estimable.
Determined by the proportional hazards method.