Association results for 2-digit HLA alleles and BCP-ALL risk
| . | Cases, no. (%) . | Controls, no. (%) . | OR (95% CI) . | Pr (> t ) . |
|---|---|---|---|---|
| Class I | ||||
| HLA-A | ||||
| 01 | 331 (21.6) | 1824 (20.6) | 1.06 (0.93-1.21) | 0.38 |
| 11 | 103 (6.7) | 555 (6.3) | 1.08 (0.87-1.34) | 0.50 |
| 02 | 402 (26.2) | 2319 (26.1) | 1.00 (0.89-1.13) | 0.98 |
| 23 | 21 (1.4) | 119 (1.3) | 1.02 (0.64-1.63) | 0.94 |
| 24 | 133 (8.7) | 737 (8.3) | 1.05 (0.86-1.27) | 0.65 |
| 25 | 29 (1.9) | 182 (2.1) | 0.92 (0.62-1.36) | 0.67 |
| 26* | 16 (1.0) | 161 (1.8) | 0.57 (0.34-0.95) | 0.03 |
| 29* | 83 (5.4) | 370 (4.2) | 1.31 (1.03-1.68) | 0.03 |
| 03 | 221 (14.4) | 1348 (15.2) | 0.94 (0.80-1.09) | 0.41 |
| 30 | 26 (1.7) | 200 (2.3) | 0.75 (0.49-1.13) | 0.16 |
| 31 | 61 (4.0) | 269 (3.0) | 1.32 (1.00-1.76) | 0.05 |
| 32 | 56 (3.6) | 357 (4.0) | 0.90 (0.68-1.20) | 0.48 |
| 68 | 49 (3.2) | 359 (4.0) | 0.78 (0.58-1.06) | 0.11 |
| HLA-B | ||||
| 13 | 32 (2.0) | 182 (2.0) | 1.01 (0.69-1.48) | 0.95 |
| 14 | 48 (3.0) | 365 (4.0) | 0.75 (0.55-1.02) | 0.06 |
| 15 | 122 (7.7) | 670 (7.3) | 1.05 (0.86-1.29) | 0.62 |
| 18 | 69 (4.3) | 374 (4.1) | 1.07 (0.82-1.38) | 0.64 |
| 27 | 65 (4.1) | 421 (4.6) | 0.88 (0.68-1.15) | 0.37 |
| 35 | 106 (6.7) | 555 (6.1) | 1.11 (0.89-1.37) | 0.35 |
| 37 | 31 (1.9) | 130 (1.4) | 1.38 (0.93-2.05) | 0.11 |
| 38 | 17 (1.1) | 66 (0.7) | 1.49 (0.87-2.54) | 0.15 |
| 39 | 21 (1.3) | 107 (1.2) | 1.13 (0.71-1.81) | 0.61 |
| 40 | 108 (6.8) | 634 (6.9) | 0.98 (0.79-1.21) | 0.85 |
| 44 | 267 (16.8) | 1566 (17.1) | 0.98 (0.85-1.13) | 0.76 |
| 49 | 17 (1.1) | 103 (1.1) | 0.95 (0.57-1.59) | 0.84 |
| 51 | 57 (3.6) | 364 (4.0) | 0.90 (0.68-1.19) | 0.46 |
| 55 | 28 (1.8) | 178 (1.9) | 0.90 (0.60-1.35) | 0.62 |
| 57 | 73 (4.6) | 381 (4.2) | 1.11 (0.86-1.43) | 0.43 |
| 07 | 242 (15.2) | 1380 (15.0) | 1.01 (0.87-1.17) | 0.88 |
| 08 | 234 (14.7) | 1358 (14.8) | 0.99 (0.85-1.15) | 0.90 |
| HLA-C | ||||
| 01 | 46 (2.9) | 346 (3.8) | 0.77 (0.56-1.05) | 0.10 |
| 12 | 63 (4.0) | 313 (3.4) | 1.18 (0.89-1.55) | 0.24 |
| 15 | 22 (1.4) | 155 (1.7) | 0.82 (0.53-1.29) | 0.40 |
| 16 | 80 (5.1) | 400 (4.4) | 1.17 (0.92-1.50) | 0.21 |
| 02* | 74 (4.7) | 333 (3.6) | 1.31 (1.01-1.69) | 0.04 |
| 03 | 213 (13.6) | 1287 (14.1) | 0.96 (0.82-1.12) | 0.58 |
| 04 | 138 (8.8) | 768 (8.4) | 1.05 (0.87-1.27) | 0.62 |
| 05 | 156 (9.9) | 997 (10.9) | 0.90 (0.75-1.08) | 0.25 |
| 06 | 169 (10.8) | 874 (9.6) | 1.14 (0.96-1.36) | 0.14 |
| 07 | 552 (35.1) | 3183 (34.8) | 1.01 (0.91-1.13) | 0.81 |
| 08* | 41 (2.6) | 361 (3.9) | 0.65 (0.47-0.90) | 0.01 |
| Class II | ||||
| HLA-DQA | ||||
| 01 | 577 (37) | 3325 (37.5) | 0.98 (0.87-1.09) | 0.70 |
| 02 | 259 (16.6) | 1423 (16.0) | 1.04 (0.90-1.20) | 0.59 |
| 03 | 313 (20.1) | 1742 (19.6) | 1.03 (0.90-1.17) | 0.70 |
| 04 | 25 (1.6) | 192 (2.2) | 0.74 (0.48-1.12) | 0.15 |
| 05 | 387 (24.8) | 2189 (24.7) | 1.01 (0.89-1.14) | 0.92 |
| HLA-DQB | ||||
| 02* | 313 (20.6) | 2194 (23.8) | 0.83 (0.72-0.95) | 5.56 × 10−3 |
| 03* | 576 (37.9) | 3210 (34.9) | 1.14 (1.02-1.27) | 0.02 |
| 04 | 26 (1.7) | 197 (2.1) | 0.80 (0.53-1.20) | 0.28 |
| 05 | 246 (16.2) | 1392 (15.1) | 1.08 (0.93-1.26) | 0.29 |
| 06 | 359 (23.6) | 2208 (24.0) | 0.98 (0.86-1.11) | 0.75 |
| HLA-DRB | ||||
| 01 | 175 (12.4) | 926 (11.0) | 1.15 (0.96-1.36) | 0.12 |
| 11 | 49 (3.5) | 344 (4.1) | 0.84 (0.62-1.15) | 0.28 |
| 12 | 25 (1.8) | 146 (1.7) | 1.02 (0.67-1.57) | 0.92 |
| 13 | 142 (10.1) | 986 (11.7) | 0.84 (0.70-1.02) | 0.07 |
| 14 | 30 (2.1) | 219 (2.6) | 0.81 (0.55-1.20) | 0.30 |
| 15 | 233 (16.5) | 1285 (15.2) | 1.10 (0.94-1.28) | 0.23 |
| 03 | 238 (16.8) | 1386 (16.4) | 1.03 (0.89-1.20) | 0.70 |
| 04 | 210 (14.9) | 1362 (16.2) | 0.91 (0.77-1.06) | 0.22 |
| 07 | 244 (17.3) | 1375 (16.3) | 1.07 (0.92-1.24) | 0.36 |
| 08 | 25 (1.8) | 197 (2.3) | 0.75 (0.49-1.15) | 0.19 |
| 09 | 21 (1.5) | 119 (1.4) | 1.05 (0.66-1.68) | 0.82 |
| . | Cases, no. (%) . | Controls, no. (%) . | OR (95% CI) . | Pr (> t ) . |
|---|---|---|---|---|
| Class I | ||||
| HLA-A | ||||
| 01 | 331 (21.6) | 1824 (20.6) | 1.06 (0.93-1.21) | 0.38 |
| 11 | 103 (6.7) | 555 (6.3) | 1.08 (0.87-1.34) | 0.50 |
| 02 | 402 (26.2) | 2319 (26.1) | 1.00 (0.89-1.13) | 0.98 |
| 23 | 21 (1.4) | 119 (1.3) | 1.02 (0.64-1.63) | 0.94 |
| 24 | 133 (8.7) | 737 (8.3) | 1.05 (0.86-1.27) | 0.65 |
| 25 | 29 (1.9) | 182 (2.1) | 0.92 (0.62-1.36) | 0.67 |
| 26* | 16 (1.0) | 161 (1.8) | 0.57 (0.34-0.95) | 0.03 |
| 29* | 83 (5.4) | 370 (4.2) | 1.31 (1.03-1.68) | 0.03 |
| 03 | 221 (14.4) | 1348 (15.2) | 0.94 (0.80-1.09) | 0.41 |
| 30 | 26 (1.7) | 200 (2.3) | 0.75 (0.49-1.13) | 0.16 |
| 31 | 61 (4.0) | 269 (3.0) | 1.32 (1.00-1.76) | 0.05 |
| 32 | 56 (3.6) | 357 (4.0) | 0.90 (0.68-1.20) | 0.48 |
| 68 | 49 (3.2) | 359 (4.0) | 0.78 (0.58-1.06) | 0.11 |
| HLA-B | ||||
| 13 | 32 (2.0) | 182 (2.0) | 1.01 (0.69-1.48) | 0.95 |
| 14 | 48 (3.0) | 365 (4.0) | 0.75 (0.55-1.02) | 0.06 |
| 15 | 122 (7.7) | 670 (7.3) | 1.05 (0.86-1.29) | 0.62 |
| 18 | 69 (4.3) | 374 (4.1) | 1.07 (0.82-1.38) | 0.64 |
| 27 | 65 (4.1) | 421 (4.6) | 0.88 (0.68-1.15) | 0.37 |
| 35 | 106 (6.7) | 555 (6.1) | 1.11 (0.89-1.37) | 0.35 |
| 37 | 31 (1.9) | 130 (1.4) | 1.38 (0.93-2.05) | 0.11 |
| 38 | 17 (1.1) | 66 (0.7) | 1.49 (0.87-2.54) | 0.15 |
| 39 | 21 (1.3) | 107 (1.2) | 1.13 (0.71-1.81) | 0.61 |
| 40 | 108 (6.8) | 634 (6.9) | 0.98 (0.79-1.21) | 0.85 |
| 44 | 267 (16.8) | 1566 (17.1) | 0.98 (0.85-1.13) | 0.76 |
| 49 | 17 (1.1) | 103 (1.1) | 0.95 (0.57-1.59) | 0.84 |
| 51 | 57 (3.6) | 364 (4.0) | 0.90 (0.68-1.19) | 0.46 |
| 55 | 28 (1.8) | 178 (1.9) | 0.90 (0.60-1.35) | 0.62 |
| 57 | 73 (4.6) | 381 (4.2) | 1.11 (0.86-1.43) | 0.43 |
| 07 | 242 (15.2) | 1380 (15.0) | 1.01 (0.87-1.17) | 0.88 |
| 08 | 234 (14.7) | 1358 (14.8) | 0.99 (0.85-1.15) | 0.90 |
| HLA-C | ||||
| 01 | 46 (2.9) | 346 (3.8) | 0.77 (0.56-1.05) | 0.10 |
| 12 | 63 (4.0) | 313 (3.4) | 1.18 (0.89-1.55) | 0.24 |
| 15 | 22 (1.4) | 155 (1.7) | 0.82 (0.53-1.29) | 0.40 |
| 16 | 80 (5.1) | 400 (4.4) | 1.17 (0.92-1.50) | 0.21 |
| 02* | 74 (4.7) | 333 (3.6) | 1.31 (1.01-1.69) | 0.04 |
| 03 | 213 (13.6) | 1287 (14.1) | 0.96 (0.82-1.12) | 0.58 |
| 04 | 138 (8.8) | 768 (8.4) | 1.05 (0.87-1.27) | 0.62 |
| 05 | 156 (9.9) | 997 (10.9) | 0.90 (0.75-1.08) | 0.25 |
| 06 | 169 (10.8) | 874 (9.6) | 1.14 (0.96-1.36) | 0.14 |
| 07 | 552 (35.1) | 3183 (34.8) | 1.01 (0.91-1.13) | 0.81 |
| 08* | 41 (2.6) | 361 (3.9) | 0.65 (0.47-0.90) | 0.01 |
| Class II | ||||
| HLA-DQA | ||||
| 01 | 577 (37) | 3325 (37.5) | 0.98 (0.87-1.09) | 0.70 |
| 02 | 259 (16.6) | 1423 (16.0) | 1.04 (0.90-1.20) | 0.59 |
| 03 | 313 (20.1) | 1742 (19.6) | 1.03 (0.90-1.17) | 0.70 |
| 04 | 25 (1.6) | 192 (2.2) | 0.74 (0.48-1.12) | 0.15 |
| 05 | 387 (24.8) | 2189 (24.7) | 1.01 (0.89-1.14) | 0.92 |
| HLA-DQB | ||||
| 02* | 313 (20.6) | 2194 (23.8) | 0.83 (0.72-0.95) | 5.56 × 10−3 |
| 03* | 576 (37.9) | 3210 (34.9) | 1.14 (1.02-1.27) | 0.02 |
| 04 | 26 (1.7) | 197 (2.1) | 0.80 (0.53-1.20) | 0.28 |
| 05 | 246 (16.2) | 1392 (15.1) | 1.08 (0.93-1.26) | 0.29 |
| 06 | 359 (23.6) | 2208 (24.0) | 0.98 (0.86-1.11) | 0.75 |
| HLA-DRB | ||||
| 01 | 175 (12.4) | 926 (11.0) | 1.15 (0.96-1.36) | 0.12 |
| 11 | 49 (3.5) | 344 (4.1) | 0.84 (0.62-1.15) | 0.28 |
| 12 | 25 (1.8) | 146 (1.7) | 1.02 (0.67-1.57) | 0.92 |
| 13 | 142 (10.1) | 986 (11.7) | 0.84 (0.70-1.02) | 0.07 |
| 14 | 30 (2.1) | 219 (2.6) | 0.81 (0.55-1.20) | 0.30 |
| 15 | 233 (16.5) | 1285 (15.2) | 1.10 (0.94-1.28) | 0.23 |
| 03 | 238 (16.8) | 1386 (16.4) | 1.03 (0.89-1.20) | 0.70 |
| 04 | 210 (14.9) | 1362 (16.2) | 0.91 (0.77-1.06) | 0.22 |
| 07 | 244 (17.3) | 1375 (16.3) | 1.07 (0.92-1.24) | 0.36 |
| 08 | 25 (1.8) | 197 (2.3) | 0.75 (0.49-1.15) | 0.19 |
| 09 | 21 (1.5) | 119 (1.4) | 1.05 (0.66-1.68) | 0.82 |
Only alleles present in > 1% of cases are shown.
Alleles showing an association with ALL risk at P < .05.