dUCB and Haplo-marrow graft characteristics
| CTN 0604 dUCB . | . |
|---|---|
| Number of patients | 50 |
| Combined pre-cryopreservation total nucleated cell count, ×107/kg | |
| Median | 5.0 |
| Range | 2.4-9.3 |
| Combined post-thaw total nucleated cell count, ×107/kg | |
| Median | 4.2 |
| Range | 2.3-13.6 |
| HLA matching | |
| 4 of 6 + 4 of 6 | 21 (42%) |
| 4 of 6 + 5 of 6 | 11 (22%) |
| 4 of 6 + 6 of 6 | 1 (2%) |
| 5 of 6 + 5 of 6 | 13 (26%) |
| 5 of 6 + 6 of 6 | 1 (2%) |
| 6 of 6 + 6 of 6 | 3 (6%) |
| HLA typing match score (1st cord to 2nd cord) | |
| 4 of 6 | 35 (70%) |
| 5 of 6 | 11 (22%) |
| 6 of 6 | 4 (8%) |
| CTN 0603 Haplo-marrow | |
| Number of patients | 50 |
| Median donor age, y (range) | 41 (19-79) |
| Donor relationship to patient | |
| Parent | 15 (30%) |
| Child | 18 (36%) |
| Sibling | 17 (34%) |
| HLA Typing match score (GVH direction) | |
| 5 of 10 | 28 (56%) |
| 6 of 10 | 12 (24%) |
| 7 of 10 | 9 (18%) |
| 8 of 10 | 1 (2%) |
| HLA typing match score (HVG direction) | |
| 5 of 10 | 22 (44%) |
| 6 of 10 | 22 (44%) |
| 7 of 10 | 3 (6%) |
| 8 of 10 | 1 (2%) |
| 9 of 10 | 1 (2%) |
| 10 of 10 | 1 (2%) |
| CTN 0604 dUCB . | . |
|---|---|
| Number of patients | 50 |
| Combined pre-cryopreservation total nucleated cell count, ×107/kg | |
| Median | 5.0 |
| Range | 2.4-9.3 |
| Combined post-thaw total nucleated cell count, ×107/kg | |
| Median | 4.2 |
| Range | 2.3-13.6 |
| HLA matching | |
| 4 of 6 + 4 of 6 | 21 (42%) |
| 4 of 6 + 5 of 6 | 11 (22%) |
| 4 of 6 + 6 of 6 | 1 (2%) |
| 5 of 6 + 5 of 6 | 13 (26%) |
| 5 of 6 + 6 of 6 | 1 (2%) |
| 6 of 6 + 6 of 6 | 3 (6%) |
| HLA typing match score (1st cord to 2nd cord) | |
| 4 of 6 | 35 (70%) |
| 5 of 6 | 11 (22%) |
| 6 of 6 | 4 (8%) |
| CTN 0603 Haplo-marrow | |
| Number of patients | 50 |
| Median donor age, y (range) | 41 (19-79) |
| Donor relationship to patient | |
| Parent | 15 (30%) |
| Child | 18 (36%) |
| Sibling | 17 (34%) |
| HLA Typing match score (GVH direction) | |
| 5 of 10 | 28 (56%) |
| 6 of 10 | 12 (24%) |
| 7 of 10 | 9 (18%) |
| 8 of 10 | 1 (2%) |
| HLA typing match score (HVG direction) | |
| 5 of 10 | 22 (44%) |
| 6 of 10 | 22 (44%) |
| 7 of 10 | 3 (6%) |
| 8 of 10 | 1 (2%) |
| 9 of 10 | 1 (2%) |
| 10 of 10 | 1 (2%) |
dUCB indicates double umbilical cord blood; and haplo-marrow, HLA-haploidentical related donor bone marrow.