Table 3 Protocol targeted grade 3-4... | American Society of Hematology

Table 3

Protocol targeted grade 3-4 toxicity day 0-180*

Organ/system	CTN 0604 dUCB no. of events (no. of patients)		CTN 0603 Haplo-marrow no. of events (no. of patients)
Organ/system	Grade 3	Grade 4	Grade 3	Grade 4
Hypertension	8 (8)	0 (0)	7 (5)	0 (0)
Hypotension	7 (6)	0 (0)	1 (1)	0 (0)
Cardiac arrhythmia	4 (3)	1 (1)	1 (1)	0 (0)
Left ventricular systolic dysfunction	3 (3)	2 (2)	0 (0)	0 (0)
Hepatic†	9 (6)	1 (1)	3 (3)	1 (1)
Pulmonary†	9 (6)	9 (6)	4 (4)	5 (2)
Hemorrhagic cystitis	5 (3)	0 (0)	3 (2)	0 (0)
Hemorrhage	0 (0)	1 (1)	0 (0)	0 (0)
Mucositis stomatitis	2 (2)	0 (0)	2 (2)	0 (0)
Somnolence	7 (5)	0 (0)	0 (0)	0 (0)
Seizure	0 (0)	0 (0)	1 (1)	0 (0)

Organ/system	CTN 0604 dUCB no. of events (no. of patients)		CTN 0603 Haplo-marrow no. of events (no. of patients)
Organ/system	Grade 3	Grade 4	Grade 3	Grade 4
Hypertension	8 (8)	0 (0)	7 (5)	0 (0)
Hypotension	7 (6)	0 (0)	1 (1)	0 (0)
Cardiac arrhythmia	4 (3)	1 (1)	1 (1)	0 (0)
Left ventricular systolic dysfunction	3 (3)	2 (2)	0 (0)	0 (0)
Hepatic†	9 (6)	1 (1)	3 (3)	1 (1)
Pulmonary†	9 (6)	9 (6)	4 (4)	5 (2)
Hemorrhagic cystitis	5 (3)	0 (0)	3 (2)	0 (0)
Hemorrhage	0 (0)	1 (1)	0 (0)	0 (0)
Mucositis stomatitis	2 (2)	0 (0)	2 (2)	0 (0)
Somnolence	7 (5)	0 (0)	0 (0)	0 (0)
Seizure	0 (0)	0 (0)	1 (1)	0 (0)

dUCB indicates double umbilical cord blood; and haplo-marrow, HLA-haploidentical related donor bone marrow.

Excludes dUCB infusional toxicity.

Hepatic indicates alanine aminotransferase and/or alkaline phosphatase; pulmonary indicates hypoxia and/or dyspnea.