microRNAs are important regulators for erythropoiesis
| microRNA . | Organism and experimental system . | Function . | Target . | Reference . |
|---|---|---|---|---|
| miR-150 | Human cord blood megakaryocyte-erythrocyte and megakaryocyte progenitor | miR-150 induces differentiation toward the megakaryocytic lineage at the expense of erythroid lineage | MYB | 70 |
| miR-221 and miR-222 | Human cord blood CD34+ cells | Down-regulation of miR-221 and miR-222 is required for terminal erythroid progenitor proliferation | KIT | 71 |
| miR-24 | Human cord blood CD34+ cells and K562 cell line | Down-regulation of miR-24 is required for terminal erythroid differentiation | ALK4 | 72 |
| miR-223 | Human cord blood CD34+ cells | Down-regulation of miR-223 is required for terminal differentiation | LMO2 | 73 |
| miR-144 | Zebrafish embryo | miR-144 is required for zebrafish embryonic α-globin gene expression | Klfd | 76 |
| miR-451 | Zebrafish embryo | miR-451 is required for zebrafish erythropoiesis | Gata2 | 75 |
| Knockout mice | miR-451 is required for steady-state erythropoiesis and resistance to oxidation during stress erythropoiesis | 14–3-3zeta | 78 | |
| miR-15a and miR-16–1 | Human cord blood CD34+ cells | miR-15a and miR-16–1 were identified as potential candidates causing elevated fetal hemoglobin expression; increased expression in elevated fetal hemoglobin gene expression | MYB | 80 |
| miR-191 | Mouse primary erythroid progenitors | The down-regulation of miR-191 is required for erythroblast chromatin condensation and enucleation | Riok3 and Mxi1 | 81 |
| microRNA . | Organism and experimental system . | Function . | Target . | Reference . |
|---|---|---|---|---|
| miR-150 | Human cord blood megakaryocyte-erythrocyte and megakaryocyte progenitor | miR-150 induces differentiation toward the megakaryocytic lineage at the expense of erythroid lineage | MYB | 70 |
| miR-221 and miR-222 | Human cord blood CD34+ cells | Down-regulation of miR-221 and miR-222 is required for terminal erythroid progenitor proliferation | KIT | 71 |
| miR-24 | Human cord blood CD34+ cells and K562 cell line | Down-regulation of miR-24 is required for terminal erythroid differentiation | ALK4 | 72 |
| miR-223 | Human cord blood CD34+ cells | Down-regulation of miR-223 is required for terminal differentiation | LMO2 | 73 |
| miR-144 | Zebrafish embryo | miR-144 is required for zebrafish embryonic α-globin gene expression | Klfd | 76 |
| miR-451 | Zebrafish embryo | miR-451 is required for zebrafish erythropoiesis | Gata2 | 75 |
| Knockout mice | miR-451 is required for steady-state erythropoiesis and resistance to oxidation during stress erythropoiesis | 14–3-3zeta | 78 | |
| miR-15a and miR-16–1 | Human cord blood CD34+ cells | miR-15a and miR-16–1 were identified as potential candidates causing elevated fetal hemoglobin expression; increased expression in elevated fetal hemoglobin gene expression | MYB | 80 |
| miR-191 | Mouse primary erythroid progenitors | The down-regulation of miR-191 is required for erythroblast chromatin condensation and enucleation | Riok3 and Mxi1 | 81 |