Thrombin substrates and ligands1-3
| Thrombin substrate or binding partner . | ABE I . | ABE II . | Comments . |
|---|---|---|---|
| Fibrinogen | + | — | |
| Fibrinogen-γ′ | + | + | 10% of total fibrinogen contains γ′ chains |
| FV | + | + | IIa residues outside ABEs also involved |
| FVIII | + | + | IIa residues outside ABEs also involved |
| FXIII | — | — | Fibrin accelerates 80-fold |
| Protein C | — | — | Thrombomodulin facilitates interaction |
| TAFI | — | — | Thrombomodulin facilitates interaction |
| Heparin | — | + | |
| Antithrombin | — | — | Heparin facilitates interaction |
| Heparin cofactor II | + | — | Heparin facilitates interaction |
| Thrombomodulin | + | + | Glycosaminoglycans interact with ABE II |
| Glycoprotein 1bα | — | + | — |
| PAR-1 | + | — | — |
| PAR-4 | + | — | — |
| Thrombin substrate or binding partner . | ABE I . | ABE II . | Comments . |
|---|---|---|---|
| Fibrinogen | + | — | |
| Fibrinogen-γ′ | + | + | 10% of total fibrinogen contains γ′ chains |
| FV | + | + | IIa residues outside ABEs also involved |
| FVIII | + | + | IIa residues outside ABEs also involved |
| FXIII | — | — | Fibrin accelerates 80-fold |
| Protein C | — | — | Thrombomodulin facilitates interaction |
| TAFI | — | — | Thrombomodulin facilitates interaction |
| Heparin | — | + | |
| Antithrombin | — | — | Heparin facilitates interaction |
| Heparin cofactor II | + | — | Heparin facilitates interaction |
| Thrombomodulin | + | + | Glycosaminoglycans interact with ABE II |
| Glycoprotein 1bα | — | + | — |
| PAR-1 | + | — | — |
| PAR-4 | + | — | — |
+ indicates that ABE I or ABE II is required for the interaction; and —, an ABE interaction is not required.