Treatment-emergent adverse events during therapy
| Toxicity . | Induction therapy (N = 91) . | All treatment cycles (N = 91) . | |||
|---|---|---|---|---|---|
| Any grade . | Grade 3/4 . | Any grade . | Grade 3/4 . | SAE . | |
| Hematologic | |||||
| Blood and lymphatic system disorders | 7 (8) | 5 (5) | 15 (16) | 6 (7) | 3 (3) |
| Nonhematologic | |||||
| Gastrointestinal disorders | 49 (54) | 2 (2) | 66 (73) | 11 (12) | 8 (9) |
| General disorders and administration site conditions | 53 (58) | 2 (2) | 62 (68) | 5 (5) | 12 (13) |
| Respiratory, thoracic, and mediastinal disorders | 35 (38) | 9 (10) | 50 (54) | 14 (15) | 9 (10) |
| PNP | 33 (36) | 0 (0) | 36 (40) | 1 (1) | 2 (2) |
| Skin and subcutaneous tissue disorders | 36 (40) | 7 (8) | 41 (45) | 9 (10) | 2 (2) |
| Musculature, skeletal, and connective tissue disorders | 21 (23) | 1 (1) | 38 (42) | 4 (4) | 4 (4) |
| Vascular disorders | 24 (26) | 5 (5) | 27 (30) | 6 (7) | 2 (2) |
| Cardiac disorders | 15 (16) | 5 (5) | 17 (19) | 5 (5) | 5 (5) |
| Infections and infestations | 12 (13) | 0 (0) | 33 (36) | 3 (3) | 0 (0) |
| Metabolism and nutrition disorders | 16 (18) | 7 (8) | 19 (21) | 8 (9) | 7 (8) |
| Investigations | 6 (7) | 4 (4) | 12 (13) | 9 (10) | 0 (0) |
| Eye disorders | 9 (10) | 1 (1) | 15 (16) | 1 (1) | 0 (0) |
| Psychiatric disorders | 7 (8) | 0 (0) | 10 (11) | 0 (0) | 0 (0) |
| Renal and urinary disorders | 7 (8) | 3 (3) | 10 (11) | 3 (3) | 4 (4) |
| Endocrine disorders | 2 (2) | 0 (0) | 3 (3) | 1 (1) | 1 (1) |
| Surgical and medical procedures | 1 (1) | 1 (1) | 3 (3) | 1 (1) | 1 (1) |
| Toxicity . | Induction therapy (N = 91) . | All treatment cycles (N = 91) . | |||
|---|---|---|---|---|---|
| Any grade . | Grade 3/4 . | Any grade . | Grade 3/4 . | SAE . | |
| Hematologic | |||||
| Blood and lymphatic system disorders | 7 (8) | 5 (5) | 15 (16) | 6 (7) | 3 (3) |
| Nonhematologic | |||||
| Gastrointestinal disorders | 49 (54) | 2 (2) | 66 (73) | 11 (12) | 8 (9) |
| General disorders and administration site conditions | 53 (58) | 2 (2) | 62 (68) | 5 (5) | 12 (13) |
| Respiratory, thoracic, and mediastinal disorders | 35 (38) | 9 (10) | 50 (54) | 14 (15) | 9 (10) |
| PNP | 33 (36) | 0 (0) | 36 (40) | 1 (1) | 2 (2) |
| Skin and subcutaneous tissue disorders | 36 (40) | 7 (8) | 41 (45) | 9 (10) | 2 (2) |
| Musculature, skeletal, and connective tissue disorders | 21 (23) | 1 (1) | 38 (42) | 4 (4) | 4 (4) |
| Vascular disorders | 24 (26) | 5 (5) | 27 (30) | 6 (7) | 2 (2) |
| Cardiac disorders | 15 (16) | 5 (5) | 17 (19) | 5 (5) | 5 (5) |
| Infections and infestations | 12 (13) | 0 (0) | 33 (36) | 3 (3) | 0 (0) |
| Metabolism and nutrition disorders | 16 (18) | 7 (8) | 19 (21) | 8 (9) | 7 (8) |
| Investigations | 6 (7) | 4 (4) | 12 (13) | 9 (10) | 0 (0) |
| Eye disorders | 9 (10) | 1 (1) | 15 (16) | 1 (1) | 0 (0) |
| Psychiatric disorders | 7 (8) | 0 (0) | 10 (11) | 0 (0) | 0 (0) |
| Renal and urinary disorders | 7 (8) | 3 (3) | 10 (11) | 3 (3) | 4 (4) |
| Endocrine disorders | 2 (2) | 0 (0) | 3 (3) | 1 (1) | 1 (1) |
| Surgical and medical procedures | 1 (1) | 1 (1) | 3 (3) | 1 (1) | 1 (1) |
Data are n (%) of patients.