Cytogenetic data of CP-CML patients with ACAs in Ph+ cells at diagnosis
| No. . | Sex . | Age at diagnosis, y . | Cytogenetic aberrations in addition to the t(9;22)(q34;q11) or the variant t(v;22) at diagnosis [no. of analyzed metaphases] . |
|---|---|---|---|
| 1 | M | 60 | 46,XY,t(9;22)(q34;q11),del(15)(q22),add(17)(p11)[8] |
| 2 | F | 53 | 46,XX,t(3;12)(p14;q23),t(9;22)(q34;q11)[16]/46,XX[4] |
| 3 | M | 48 | 46,XY,t(4;6)(q21;p23),t(9;22)(q34;q11)[20] |
| 4 | M | 47 | 46,XY,t(9;22)(q34;q11),t(14;17)(p11;p11)[20] |
| 5 | M | 46 | 46,XY,der(9)t(9;22)(q34;q11)del(9)(q33q34),del(22)(q11q12), der(22)t(9;22)(q34;q11)[20] |
| 6 | M | 27 | 45,XY,t(9;22)(q34;q11),-21[4]/46,XY[16] |
| 7 | F | 52 | 46,XX,t(2;16)(p2?3;p1?3),t(9;22)(q34;q11)[24] |
| 8 | M | 30 | 46,XY,der(9)inv(9)(p22q34)t(9;22)(q34;q11),der(22)t(9;22)(q34;q11)[15] |
| 9 | F | 56 | 46,XX,t(1;21)(q21;q22),t(9;22)(q34;q11)[20] |
| 10 | F | 60 | 46,XX,t(1;9)(q24;q31)t(9;22)(q34;q11)[15]/46,XX[5] |
| 11 | F | 46 | 46,XX,der(2)t(2;4)(q37;q21),del(4)(q21),t(9;22)(q34;q11)[20] |
| 12 | F | 56 | 46,XX,der(9)add(9)(p23)t(9;22)(q34;q11)inv(9)(p23q34),der(22)t(9;22)(q34;q11)[15] |
| 13 | F | 70 | 46,XX,t(9;22)(q34;q11),t(10;22)(q25;q13)[17] |
| 14 | M | 49 | 92,XXYY,i(7)(q10)x2,t(9;22)(q34;q11)x2[5]/46,XY[14] |
| 15 | F | 48 | 46,XX,der(1)t(1;22)(p36;q11),der(2)t(2;13)(p16;?)dup(2)(q11q31),del(2)(p13),der(22)t(2;22)(p13;q11)[15] |
| 16 | F | 43 | 46,XX,t(7;7)(p22;q22),t(9;22;9)(q34;q11;p24)[16]/46,XX[20] |
| 17 | F | 38 | 46,XX,del(1)(q21),t(9;22;1)(q34;q11;q21)[20] |
| 18 | F | 18 | 46,XX,t(8;9)(q24;p22),der(9)del(9)(q13q22)t(8;9)(q24;p22),der(20)t(9;20)(q13q22;q13);t(?;9;22)(?;q34;q11)[16]/47,XX,idem,+10[2] |
| 19 | F | 61 | 46,XX,t(9;22)(q34;q11)[21]/46,XX,del(6)(q15q23),t(9;22)(q34;q11)[4] |
| 20 | F | 68 | 46,XX,del(5)(q13q22),t(9;22)(q34;q11)[24] |
| 21 | M | 42 | 46,XY,inv(3)(p13q25),t(9;22)(q34;q11)[17] |
| 22 | M | 36 | 46,XY,t(9;22)(q34;q11),t(11;19)(q14.1;q13)[16] |
| 23 | F | 49 | 46,XX,del(3)(p11p21),t(9,22)(q34;q11)[13] |
| 24 | M | 44 | 46,XY,t(9;22)(q34;q11)[17]/46,XY,dup(1)(q31q21),t(9;22)(q34;q11)[3] |
| 25 | F | 47 | 46,XX,t(9;22)(q34;q11)[2]/46,XX,der(7;11)ins(7;11)(p14;p11q25)t(7;11)(p22;p11),t(9;22)(q34;q11)[13] |
| 26 | M | 59 | 46,XY,der(9)t(9;22)(q34;q11),ider(22)(q10)t(9;22)(q34;q11)[11]/46,XY[14] |
| 27 | M | 39 | 48,XY,+8,t(9;22)(q34;q11),i(17)(q10),+der(22)t(9;22)(q34;q11)[10]/46,XY[4] |
| 28 | M | 72 | 47,XY,+8,t(9;22)(q34;q11)[20] |
| 29 | M | 28 | 50,XY,+8,+8,t(9;22)(q34;q11),i(17)(q10),+19,+der(22)t(9;22)(q34;q11)[6]/46,XX[22] |
| 30 | M | 53 | 46,XY,der(9)t(9;22)(q34;q11),idicder(22)(q11)t(9;22)(q34;q11)[22]/46,XY[3] |
| 31 | M | 40 | 47,XY,+8,t(9;22)(q34;q11)[19]/46,XY[6] |
| 32 | M | 41 | 44,XY,t(9;22)(q34;q11),-14,i(17)(q10),-18[15]/46,XY[11] |
| 33 | M | 23 | 47,XY,t(9;22)(q34;q11),+der(22)t(9;22)(q34;q11)[2]/46,XY[18] |
| 34 | F | 59 | 47,XX,+8,t(9;22)(q34;q11)[2]/46,XX[23] |
| 35 | M | 48 | 46,XY,t(9;22)(q34;q11)[6]/47,XY,+8,t(9;22)(q34;q11)[12]/46,XY[2] |
| 36 | M | 31 | 46,XY,t(9;22;10)(q34;q11;p15)[13];55,XY,+3,+8,t(9;22;10)(q34;q11;p15),+12,+13,+14,+18,+19,+21,+der(22)t(9;22;10)(q34;q11;p15)[7] |
| 37 | M | 37 | 46,XY,t(9;22)(q34;q11)[10]/47,XY,t(9;22)(q34;q11),+der(22)t(9;22)(q34;q11)[10] |
| 38 | M | 28 | 47,XY,t(9;22)(q34;q11),+der(22)t(9;22)(q34;q11)[20] |
| 39 | M | 51 | 46,XY,t(9;22)(q34;q11)[8]/47,XY,+8,t(9;22)(q34;q11),i(17)(q10)[18] |
| 40 | F | 52 | 47,XX,+8,t(9;22)(q34,q11),i(17)(q10)[10] |
| 41 | F | 69 | 46,XX,t(9;22)(q34;q11)[9]/46,XX,der(9)t(9;22)(q34;q11),ider(22)(q10)t(9;22)(q34;q11)[13] |
| No. . | Sex . | Age at diagnosis, y . | Cytogenetic aberrations in addition to the t(9;22)(q34;q11) or the variant t(v;22) at diagnosis [no. of analyzed metaphases] . |
|---|---|---|---|
| 1 | M | 60 | 46,XY,t(9;22)(q34;q11),del(15)(q22),add(17)(p11)[8] |
| 2 | F | 53 | 46,XX,t(3;12)(p14;q23),t(9;22)(q34;q11)[16]/46,XX[4] |
| 3 | M | 48 | 46,XY,t(4;6)(q21;p23),t(9;22)(q34;q11)[20] |
| 4 | M | 47 | 46,XY,t(9;22)(q34;q11),t(14;17)(p11;p11)[20] |
| 5 | M | 46 | 46,XY,der(9)t(9;22)(q34;q11)del(9)(q33q34),del(22)(q11q12), der(22)t(9;22)(q34;q11)[20] |
| 6 | M | 27 | 45,XY,t(9;22)(q34;q11),-21[4]/46,XY[16] |
| 7 | F | 52 | 46,XX,t(2;16)(p2?3;p1?3),t(9;22)(q34;q11)[24] |
| 8 | M | 30 | 46,XY,der(9)inv(9)(p22q34)t(9;22)(q34;q11),der(22)t(9;22)(q34;q11)[15] |
| 9 | F | 56 | 46,XX,t(1;21)(q21;q22),t(9;22)(q34;q11)[20] |
| 10 | F | 60 | 46,XX,t(1;9)(q24;q31)t(9;22)(q34;q11)[15]/46,XX[5] |
| 11 | F | 46 | 46,XX,der(2)t(2;4)(q37;q21),del(4)(q21),t(9;22)(q34;q11)[20] |
| 12 | F | 56 | 46,XX,der(9)add(9)(p23)t(9;22)(q34;q11)inv(9)(p23q34),der(22)t(9;22)(q34;q11)[15] |
| 13 | F | 70 | 46,XX,t(9;22)(q34;q11),t(10;22)(q25;q13)[17] |
| 14 | M | 49 | 92,XXYY,i(7)(q10)x2,t(9;22)(q34;q11)x2[5]/46,XY[14] |
| 15 | F | 48 | 46,XX,der(1)t(1;22)(p36;q11),der(2)t(2;13)(p16;?)dup(2)(q11q31),del(2)(p13),der(22)t(2;22)(p13;q11)[15] |
| 16 | F | 43 | 46,XX,t(7;7)(p22;q22),t(9;22;9)(q34;q11;p24)[16]/46,XX[20] |
| 17 | F | 38 | 46,XX,del(1)(q21),t(9;22;1)(q34;q11;q21)[20] |
| 18 | F | 18 | 46,XX,t(8;9)(q24;p22),der(9)del(9)(q13q22)t(8;9)(q24;p22),der(20)t(9;20)(q13q22;q13);t(?;9;22)(?;q34;q11)[16]/47,XX,idem,+10[2] |
| 19 | F | 61 | 46,XX,t(9;22)(q34;q11)[21]/46,XX,del(6)(q15q23),t(9;22)(q34;q11)[4] |
| 20 | F | 68 | 46,XX,del(5)(q13q22),t(9;22)(q34;q11)[24] |
| 21 | M | 42 | 46,XY,inv(3)(p13q25),t(9;22)(q34;q11)[17] |
| 22 | M | 36 | 46,XY,t(9;22)(q34;q11),t(11;19)(q14.1;q13)[16] |
| 23 | F | 49 | 46,XX,del(3)(p11p21),t(9,22)(q34;q11)[13] |
| 24 | M | 44 | 46,XY,t(9;22)(q34;q11)[17]/46,XY,dup(1)(q31q21),t(9;22)(q34;q11)[3] |
| 25 | F | 47 | 46,XX,t(9;22)(q34;q11)[2]/46,XX,der(7;11)ins(7;11)(p14;p11q25)t(7;11)(p22;p11),t(9;22)(q34;q11)[13] |
| 26 | M | 59 | 46,XY,der(9)t(9;22)(q34;q11),ider(22)(q10)t(9;22)(q34;q11)[11]/46,XY[14] |
| 27 | M | 39 | 48,XY,+8,t(9;22)(q34;q11),i(17)(q10),+der(22)t(9;22)(q34;q11)[10]/46,XY[4] |
| 28 | M | 72 | 47,XY,+8,t(9;22)(q34;q11)[20] |
| 29 | M | 28 | 50,XY,+8,+8,t(9;22)(q34;q11),i(17)(q10),+19,+der(22)t(9;22)(q34;q11)[6]/46,XX[22] |
| 30 | M | 53 | 46,XY,der(9)t(9;22)(q34;q11),idicder(22)(q11)t(9;22)(q34;q11)[22]/46,XY[3] |
| 31 | M | 40 | 47,XY,+8,t(9;22)(q34;q11)[19]/46,XY[6] |
| 32 | M | 41 | 44,XY,t(9;22)(q34;q11),-14,i(17)(q10),-18[15]/46,XY[11] |
| 33 | M | 23 | 47,XY,t(9;22)(q34;q11),+der(22)t(9;22)(q34;q11)[2]/46,XY[18] |
| 34 | F | 59 | 47,XX,+8,t(9;22)(q34;q11)[2]/46,XX[23] |
| 35 | M | 48 | 46,XY,t(9;22)(q34;q11)[6]/47,XY,+8,t(9;22)(q34;q11)[12]/46,XY[2] |
| 36 | M | 31 | 46,XY,t(9;22;10)(q34;q11;p15)[13];55,XY,+3,+8,t(9;22;10)(q34;q11;p15),+12,+13,+14,+18,+19,+21,+der(22)t(9;22;10)(q34;q11;p15)[7] |
| 37 | M | 37 | 46,XY,t(9;22)(q34;q11)[10]/47,XY,t(9;22)(q34;q11),+der(22)t(9;22)(q34;q11)[10] |
| 38 | M | 28 | 47,XY,t(9;22)(q34;q11),+der(22)t(9;22)(q34;q11)[20] |
| 39 | M | 51 | 46,XY,t(9;22)(q34;q11)[8]/47,XY,+8,t(9;22)(q34;q11),i(17)(q10)[18] |
| 40 | F | 52 | 47,XX,+8,t(9;22)(q34,q11),i(17)(q10)[10] |
| 41 | F | 69 | 46,XX,t(9;22)(q34;q11)[9]/46,XX,der(9)t(9;22)(q34;q11),ider(22)(q10)t(9;22)(q34;q11)[13] |
ACAs except −Y. Patients 1-25 show minor-route ACAs in addition to the standard or variant translocation; patients 26-41 show major-route ACAs. Cytogenetic analyses were made and interpreted according to ISCN 2009.29
No. indicates number of patients; F, female; M, male; and CP, chronic phase.